公开(公告)号：US07750151B2

公开(公告)日：2010-07-06

申请号：US11547113

申请日：2005-04-05

Applicant: Mark T. Bilodeau ,  Chixu Chen ,  Nicholas D. P. Cosford ,  Brian W. Eastman ,  John C. Hartnett ,  Essa H. Hu ,  Peter J. Manley ,  Lou Anne Neilson ,  Lida R. Tehrani ,  Zhicai Wu

Inventor： Mark T. Bilodeau ,  Chixu Chen ,  Nicholas D. P. Cosford ,  Brian W. Eastman ,  John C. Hartnett ,  Essa H. Hu ,  Peter J. Manley ,  Lou Anne Neilson ,  Lida R. Tehrani ,  Zhicai Wu

IPC: C07D471/04 ,  C07D413/12 ,  C07D521/00 ,  C07D401/14 ,  C07D487/08 ,  A61P35/00

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: The present invention is directed to compounds which contain substituted napthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

Abstract translation: 本发明涉及含有抑制Akt（丝氨酸/苏氨酸蛋白激酶）活性的取代萘啶的化合物。 本发明还涉及含有本发明化合物的治疗组合物和治疗癌症的方法，包括施用本发明化合物。

公开(公告)号：US20090325936A1

公开(公告)日：2009-12-31

申请号：US12519789

申请日：2007-12-14

Applicant: Mark T. Bilodeau ,  Christopher S. Burgey ,  Zhengwu James Deng ,  Nathan R. Kett ,  Jeffrey Melamed ,  Peter M. Munson ,  Kausik K. Nanda ,  Wayne Thompson ,  B. Wesley Trotter ,  Zhicai Wu ,  John C. Hartnett

Inventor： Mark T. Bilodeau ,  Christopher S. Burgey ,  Zhengwu James Deng ,  Nathan R. Kett ,  Jeffrey Melamed ,  Peter M. Munson ,  Kausik K. Nanda ,  Wayne Thompson ,  B. Wesley Trotter ,  Zhicai Wu ,  John C. Hartnett

IPC: A61K31/437 ,  C07D471/04 ,  A61K31/506 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/541 ,  A61P19/00 ,  A61P25/00

CPC classification number: C07D471/04

Abstract: The present invention relates to compounds represented by Formula (I) and Formula (II): (I) (II) or pharmaceutically acceptable salts thereof. The present invention also provides pharmaceutical compositions comprising the instant compounds. This invention further provides methods to treat and prevent pain, respiratory and non-respiratory diseases.

Abstract translation: 本发明涉及由式（I）和式（II）表示的化合物：（I）（II）或其药学上可接受的盐。 本发明还提供包含本发明化合物的药物组合物。 本发明还提供了治疗和预防疼痛，呼吸和非呼吸道疾病的方法。

公开(公告)号：US07125888B2

公开(公告)日：2006-10-24

申请号：US10512927

申请日：2003-04-28

Applicant: Mark T. Bilodeau ,  Mark E. Fraley ,  Zhicai Wu

Inventor： Mark T. Bilodeau ,  Mark E. Fraley ,  Zhicai Wu

IPC: A61K31/535 ,  A61K31/5513 ,  A61K31/4375 ,  C07D407/04

CPC classification number: C07D471/04

Abstract: The present invention relates to imidazopyridine compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.

Abstract translation: 本发明涉及抑制，调节和/或调节酪氨酸激酶信号转导的咪唑并吡啶化合物，含有这些化合物的组合物，及其用于治疗酪氨酸激酶依赖性疾病和病症如血管生成，癌症，肿瘤生长， 动脉粥样硬化，年龄相关性黄斑变性，糖尿病性视网膜病变，炎症性疾病等。

公开(公告)号：US08030332B2

公开(公告)日：2011-10-04

申请号：US12223353

申请日：2007-01-29

Applicant: B. Wesley Trotter ,  Richard C. A. Isaacs ,  Zhicai Wu ,  Jacob M. Hoffman ,  Mark T. Bilodeau ,  Ahren Iver Green

Inventor： B. Wesley Trotter ,  Richard C. A. Isaacs ,  Zhicai Wu ,  Jacob M. Hoffman ,  Mark T. Bilodeau ,  Ahren Iver Green

IPC: C07D401/14 ,  A61K31/506

CPC classification number: C07D413/14

Abstract: The present invention relates to dipyridin-3-ylmethoxy compounds and derivatives thereof having the structure I useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.

Abstract translation: 本发明涉及具有用作治疗心律失常的钾通道抑制剂的结构I的二吡啶-3-基甲氧基化合物及其衍生物等。

公开(公告)号：US20100099673A1

公开(公告)日：2010-04-22

申请号：US12523192

申请日：2008-01-11

Applicant: Mark T. Bilodeau ,  Nathan R. Kett ,  Craig Lindsley ,  Peter J. Manley ,  Jeffrey Y. Melamed ,  Daniel Vincent Paone ,  B. Wesley Trotter ,  Zhicai Wu

Inventor： Mark T. Bilodeau ,  Nathan R. Kett ,  Craig Lindsley ,  Peter J. Manley ,  Jeffrey Y. Melamed ,  Daniel Vincent Paone ,  B. Wesley Trotter ,  Zhicai Wu

IPC: C07D215/02 ,  A61K31/47 ,  C07D401/02 ,  A61K31/497 ,  A61K31/498 ,  A61K31/5377 ,  C07D413/02 ,  A61P29/00 ,  A61P19/10 ,  A61P9/00 ,  A61P37/00 ,  A61P19/02

CPC classification number: C07D413/06 ,  C07D215/08 ,  C07D215/233 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/10 ,  C07D403/12 ,  C07D405/06 ,  C07D405/10 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D413/12 ,  C07D417/06 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

Abstract: The present invention relates to compounds represented by Formula (I): and pharmaceutically acceptable salts thereof. The present invention also provides pharmaceutical compositions comprising the instant compounds. This invention further provides methods to treat and prevent pain, respiratory and non-respiratory diseases.

Abstract translation: 本发明涉及由式（I）表示的化合物及其药学上可接受的盐。 本发明还提供包含本发明化合物的药物组合物。 本发明还提供了治疗和预防疼痛，呼吸和非呼吸道疾病的方法。

公开(公告)号：US07569589B2

公开(公告)日：2009-08-04

申请号：US11188466

申请日：2005-07-25

Applicant: Mark T. Bilodeau ,  Christopher J. Dinsmore ,  Jeffrey M. Bergman ,  B. Wesley Trotter ,  Lou Anne Neilson ,  Zhicai Wu ,  Peter Manley ,  John Hartnett

Inventor： Mark T. Bilodeau ,  Christopher J. Dinsmore ,  Jeffrey M. Bergman ,  B. Wesley Trotter ,  Lou Anne Neilson ,  Zhicai Wu ,  Peter Manley ,  John Hartnett

IPC: C07D403/14 ,  A61K31/44

CPC classification number: C07D213/57 ,  C07D213/06 ,  C07D213/30 ,  C07D213/42 ,  C07D213/61 ,  C07D213/64 ,  C07D213/73 ,  C07D213/74 ,  C07D213/75 ,  C07D213/76 ,  C07D213/81 ,  C07D213/84 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.

Abstract translation: 本发明涉及具有用作治疗心律失常的钾通道抑制剂的结构的化合物等。

公开(公告)号：US20080280899A1

公开(公告)日：2008-11-13

申请号：US11547113

申请日：2005-04-05

Applicant: Mark T. Bilodeau ,  Chixu Chen ,  Nicholas D.P. Cosford ,  Brian W. Eastman ,  John C. Hartnett ,  Essa H. Hu ,  Peter J. Manley ,  Lou Anne Neilson ,  Lida R. Tehrani ,  Zhicai Wu

Inventor： Mark T. Bilodeau ,  Chixu Chen ,  Nicholas D.P. Cosford ,  Brian W. Eastman ,  John C. Hartnett ,  Essa H. Hu ,  Peter J. Manley ,  Lou Anne Neilson ,  Lida R. Tehrani ,  Zhicai Wu

IPC: A61K31/519 ,  C07D471/04 ,  A61K31/4375 ,  A61P35/00 ,  A61K31/5377 ,  C07D413/12

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: The present invention is directed to compounds which contain substituted napthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

Abstract translation: 本发明涉及含有抑制Akt（丝氨酸/苏氨酸蛋白激酶）活性的取代萘啶的化合物。 本发明还涉及含有本发明化合物的治疗组合物和治疗癌症的方法，包括施用本发明化合物。

公开(公告)号：US07223738B2

公开(公告)日：2007-05-29

申请号：US10510069

申请日：2003-04-04

Applicant: Mark T. Bilodeau ,  Mark E. Duggan ,  John C. Hartnett ,  Craig W. Lindsley ,  Peter J. Manley ,  Zhicai Wu ,  Zhijian Zhao

Inventor： Mark T. Bilodeau ,  Mark E. Duggan ,  John C. Hartnett ,  Craig W. Lindsley ,  Peter J. Manley ,  Zhicai Wu ,  Zhijian Zhao

IPC: A01N43/04 ,  A01N43/58 ,  A01N43/60 ,  A01N43/42 ,  A61K31/70 ,  A61K31/50 ,  A61K31/495 ,  A61K31/52 ,  A61K31/47 ,  C07D487/00 ,  C07D491/00 ,  C07H15/00 ,  C07H17/00 ,  C07H17/02 ,  C09B25/00

CPC classification number: C07D401/10 ,  A61K31/498 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04

Abstract: The present invention is directed to compounds comprising a 2,3-diphenylquinoxaline moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

公开(公告)号：US07638530B2

公开(公告)日：2009-12-29

申请号：US10554185

申请日：2004-04-20

Applicant: Mark T. Bilodeau ,  Zhicai Wu

Inventor： Mark T. Bilodeau ,  Zhicai Wu

IPC: A61K31/4745 ,  C07D498/02 ,  C07D491/02 ,  C07D471/02

CPC classification number: C07D487/04 ,  C07D471/04

Abstract: The present invention is directed to compounds which contain a five-membered heterocyclic ring fused to a substituted pyridine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

Abstract translation: 本发明涉及含有与取代的吡啶部分稠合的五元杂环的化合物，所述取代吡啶部分抑制丝氨酸/苏氨酸蛋白激酶Akt的活性。 本发明还涉及含有本发明化合物的治疗组合物和治疗癌症的方法，包括施用本发明化合物。

公开(公告)号：US07579355B2

公开(公告)日：2009-08-25

申请号：US10554001

申请日：2004-04-20

Applicant: Mark T. Bilodeau ,  Mark E. Duggan ,  John C. Hartnett ,  Craig W. Lindsley ,  Zhicai Wu ,  Zhijian Zhao

Inventor： Mark T. Bilodeau ,  Mark E. Duggan ,  John C. Hartnett ,  Craig W. Lindsley ,  Zhicai Wu ,  Zhijian Zhao

IPC: A61K31/52 ,  C07D401/14

CPC classification number: C07F9/65583 ,  A61K45/06 ,  C07D401/04 ,  C07D401/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04

Abstract: The present invention is directed to compounds which contain a substituted pyridine moeity which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

Abstract translation: 本发明涉及含有抑制Akt（丝氨酸/苏氨酸蛋白激酶）活性的取代吡啶甲氧基化合物。 本发明还涉及含有本发明化合物的治疗组合物和治疗癌症的方法，包括施用本发明化合物。