公开(公告)号：US20230091480A1

公开(公告)日：2023-03-23

申请号：US17931711

申请日：2022-09-13

Applicant: Korea Advanced Institute of Science and Technology

Inventor： Jae-Byum JANG ,  Hyunwoo KIM ,  Young-Gyu YOON ,  Hoyeon NAM ,  Junyoung SEO

IPC: G01N21/64

Abstract: The present disclosure relates to a method and device for unmixing fluorescent signals based on a joint histogram. The method and device may be configured to obtain a plurality of images of a plurality of fluorescent materials marked in different biomolecules and to unmix the signals of the fluorescent materials based on at least one joint histogram index defined between the images of each of pairs each including two or more of the obtained images. According to the present disclosure, the joint histogram index may include at least one of Kullback-Leibler divergence, cross-entropy, or Rand-index.

公开(公告)号：US20240257346A1

公开(公告)日：2024-08-01

申请号：US18602661

申请日：2024-03-12

Applicant: Korea Advanced Institute Of Science and Technology

Inventor： JaeByum CHANG ,  Hyunwoo KIM ,  Junyoung SEO ,  Young-Gyu YOON ,  Hoyeon NAM

IPC: G06T7/00

CPC classification number: G06T7/0012 ,  G06T2207/10064 ,  G06T2207/20081 ,  G06T2207/20084

Abstract: As an aspect of the present disclosure, a method of processing an image may be proposed. The method is a method of processing an image, which is performed by an electronic device including one or more processors and one or more memories in which instructions to be executed by the one or more processors are stored, and may include obtaining a first mixed image of a sample including a first biomolecule labeled with a first fluorescent material and a second biomolecule that has not been labeled, obtaining a second mixed image of the sample including the first biomolecule labeled with the first fluorescent material and the second biomolecule labeled with a second fluorescent material, and generating an unmixed image of the second biomolecule based on the first mixed image and the second mixed image.