公开(公告)号：US20190382817A1

公开(公告)日：2019-12-19

申请号：US16483430

申请日：2018-12-12

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sang Yup LEE ,  Xin Rui ZHAO ,  Kyeong Rok CHOI

IPC: C12P17/18 ,  C12P13/00 ,  C12N9/00 ,  C12N9/02 ,  C12N9/90 ,  C12N9/88 ,  C12N9/10 ,  C12N15/67

Abstract: The present invention relates to a microorganism variant having the ability to extracellularly produce heme, and more particularly to a metabolically engineered microorganism variant having the ability to extracellularly produce heme and a method of producing heme using the same. According to the present invention, heme, an organometallic compound which is increasingly used as a health food or food supplement for the treatment of porphyria, can be extracellularly secreted and produced in high yield using the microorganism variant, but not conventional chemical synthesis or enzymatic synthesis.