公开(公告)号：US20200230261A1

公开(公告)日：2020-07-23

申请号：US16343043

申请日：2018-05-14

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sang Yong JON ,  Dong Yun LEE ,  Yong Hyun LEE ,  Do Hyun YOO ,  Won Sik JUNG

IPC: A61K49/10 ,  G01N33/72 ,  A61K33/243 ,  A61K33/26 ,  A61K33/242 ,  A61K47/22

Abstract: The present invention provides hydrophilic bilirubin derivative particles containing a metal, a use thereof, and a preparation method therefor. The bilirubin derivative particles of the present invention form coordinate bonds with various metals, and thus can be used in MR diagnosis, CT diagnosis, photo-acoustic diagnosis, PET diagnosis, or optical diagnosis. The bilirubin derivative particles of the present invention can release an anticancer drug encapsulated therein to the outside by the combination with a platinum-based anticancer drug and the degradation by a stimulation of light/reactive oxygen species, and exhibit anti-inflammatory and anticancer activities, and thus the bilirubin derivative particles of the present invention have a concept of theranostics in which the bilirubin derivative particles can be for therapeutic uses as well as diagnostic uses.