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公开(公告)号：US20240197859A1
公开(公告)日：2024-06-20
申请号：US18553308
申请日：2022-03-31
发明人： Johannes Petrus Maria Langedijk , Mark Johannes Gerardus Bakkers , Tina Ritschel , Jaroslaw Juraszek
IPC分类号： A61K39/155 , A61K39/00 , C07K14/005 , C12N7/00 , C12N15/86
CPC分类号： A61K39/155 , C07K14/005 , C12N7/00 , C12N15/86 , A61K2039/53 , C07K2319/35 , C12N2710/10343 , C12N2760/18622 , C12N2760/18634
摘要： The present invention relates to stabilized pre-fusion human parainfluenza virus 3 (HPIV3) F protein, and fragments thereof. The invention also relates to nucleic acid molecules encoding such proteins and fragments, and to the use of the proteins, fragments and nucleic acid molecules.
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公开(公告)号：US10953087B2
公开(公告)日：2021-03-23
申请号：US16305169
申请日：2017-05-29
IPC分类号： A61K39/00 , C07K14/005 , A61K39/155 , C07K16/10 , C12N7/00 , C07K14/135
摘要： Stable pre-fusion respiratory syncitial virus (RSV) F proteins, immunogenic compositions including the proteins and uses thereof for the prevention and/or treatment of RSV infection are described.
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公开(公告)号：US11905314B2
公开(公告)日：2024-02-20
申请号：US17814871
申请日：2022-07-26
发明人： Ferdinand Jacobus Milder , Tina Ritschel , Boerries Brandenburg , Mandy Antonia Catharina Jongeneelen , Daphné Truan , Johannes Petrus Maria Langedijk
IPC分类号： C07K14/005 , C07K14/11 , C07K16/10 , C07K19/00 , A61K39/145 , A61P31/16 , C12N7/00
CPC分类号： C07K14/005 , A61K39/145 , A61P31/16 , C12N7/00 , C12N2760/16122 , C12N2760/16134
摘要： Provided herein are influenza hemagglutinin stem polypeptides, nucleic acids encoding said polypeptides, vectors comprising said nucleic acid and pharmaceutical compositions comprising the same, as well as methods of their use, in particular in the prevention and/or treatment of influenza virus infections.
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公开(公告)号：US11801297B2
公开(公告)日：2023-10-31
申请号：US17664290
申请日：2022-05-20
CPC分类号： A61K39/12 , A61K2039/5256 , A61K2039/53 , C12N2710/10041 , C12N2760/18522 , C12N2760/18534 , C12N2760/18571
摘要： The present invention relates to novel nucleic acid molecules encoding a pre-fusion RSV F protein or immunologically active part thereof, wherein the pre-fusion RSV F protein comprises the amino acid sequence of SEQ ID NO: 1 or 2. The invention further relates to the use of the nucleic acid molecules, or vectors comprising said nucleic acid molecules, as a vaccine against respiratory syncytial virus (RSV).
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公开(公告)号：US10729757B2
公开(公告)日：2020-08-04
申请号：US16091257
申请日：2017-04-04
摘要： Novel nucleic acid molecules encoding a pre-fusion RSV F protein or immunologically active part thereof are described, and the pre-fusion RSV F protein contains the amino acid sequence of SEQ ID NO: 1 or 2. Use of the nucleic acid molecules, or vectors containing the nucleic acid molecules, as a vaccine against respiratory syncytial virus (RSV) is also described.
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公开(公告)号：US10711042B2
公开(公告)日：2020-07-14
申请号：US16701429
申请日：2019-12-03
IPC分类号： A61K39/12 , A61K39/00 , A61K39/155 , C12N7/00 , C07K14/005 , A61P31/16 , A61P31/22 , A61P31/18
摘要： Stable pre-fusion class I fusion proteins in the pre-fusion conformation, including one or more mutations in the hinge-loop that is present between the base helix and the RR1, are described.
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公开(公告)号：US11896663B2
公开(公告)日：2024-02-13
申请号：US17190569
申请日：2021-03-03
发明人： Johannes Petrus Maria Langedijk , Danielle Van Manen , Jort Vellinga , Frank Wegmann , Benoit Christophe Stephan Callendret , Anders Krarup , Jörn Stitz
IPC分类号： A61K39/21 , C07K14/16 , C07K14/005 , C12N7/00 , C12N15/86 , C12N15/861 , A61K39/00
CPC分类号： A61K39/21 , C07K14/005 , C07K14/162 , C12N7/00 , C12N15/86 , A61K2039/5256 , C12N15/861 , C12N2710/10343 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12N2740/16234
摘要： Compositions and vaccine combinations containing synthetic HIV envelope proteins, and methods for inducing an immune response against human immunodeficiency virus (HIV) infection are described. Viral expression vectors encoding the synthetic HIV envelope proteins can be used in the vaccine combinations to induce immune responses against HIV and provide improved protective immunity against HIV.
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公开(公告)号：US11732010B2
公开(公告)日：2023-08-22
申请号：US17181024
申请日：2021-02-22
IPC分类号： C07K14/005 , A61K39/12 , A61K39/00 , A61P31/18
CPC分类号： C07K14/005 , A61K39/12 , A61K39/00 , A61K2039/55555 , A61P31/18 , C12N2740/16022 , C12N2740/16034 , C12N2740/16071 , C12N2740/16122 , C12N2740/16134
摘要： Human immunodeficiency virus (HIV) envelope proteins having specified mutations that stabilize the trimeric form of the envelope protein are provided. The HIV envelope proteins described herein have an improved percentage of trimer formation and/or an improved trimer yield. Also provided are particles displaying the HIV envelope proteins, nucleic acid molecules and vectors encoding the HIV envelope proteins, as well as compositions containing the HIV envelope proteins, particles, nucleic acid, or vectors.
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公开(公告)号：US11447526B2
公开(公告)日：2022-09-20
申请号：US16964089
申请日：2019-01-22
发明人： Ferdinand Jacobus Milder , Tina Ritschel , Boerries Brandenburg , Mandy Antonia Catharina Jongeneelen , Daphné Truan , Johannes Petrus Maria Langedijk
IPC分类号： A61K39/00 , C07K16/10 , A61K39/145 , A61K39/42 , C07K14/005 , A61P31/16 , C12N7/00
摘要： Provided herein are influenza hemagglutinin stem polypeptides, nucleic acids encoding said polypeptides, vectors comprising said nucleic acid and pharmaceutical compositions comprising the same, as well as methods of their use, in particular in the prevention and/or treatment of influenza virus infections.
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公开(公告)号：US20220088172A1
公开(公告)日：2022-03-24
申请号：US17643606
申请日：2021-12-10
发明人： Frank Wegmann , Johannes Petrus Maria Langedijk , Jerôme Hubertina Henricus Victor Custers , Viki Bockstal , Markus Kalla
摘要： Poxvirus vectors encoding a synthetic HIV envelope antigen and other HIV antigens, as well as compositions containing such poxvirus vectors and uses of such poxvirus vectors as vaccines to provide improved immunity against HIV, are provided. Also provided are vaccine combinations containing the disclosed poxvirus vectors, adenovirus vectors encoding one or more HIV antigens, and one or more isolated HIV antigenic polypeptides, and methods of using the vaccine combinations to provide improved immunity against HIV.
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