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公开(公告)号：US20250011438A1
公开(公告)日：2025-01-09
申请号：US18667700
申请日：2024-05-17
Applicant: Institute for Basic Science
Inventor： Gou Young Koh , Jeomil Bae , Jaeryung Kim
IPC: C07K16/28 , A61K31/713 , A61K39/00 , A61K39/395 , A61K45/06 , A61P27/06 , C12N5/10 , C12N15/63
Abstract: The present invention refers to an antibody against Tie-2 or antigen-binding fragment thereof, a nucleic acid encoding the same, a vector comprising the nucleic acid, a cell transformed with the vector, a manufacturing method of the antibody or antigen-binding fragment thereof, and a composition for preventing or treating angiogenic diseases, which comprises the antibody or antigen-binding fragment thereof.
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Patent Agency Ranking
公开(公告)号：US20230272057A1
公开(公告)日：2023-08-31
申请号：US18045964
申请日：2022-10-12
Inventor： Gou Young Koh , Jeomil Bae , Mi Jeong Kim , Jin-Sung Park , Su Jin Seo , Jaeryung Kim , Jang Ryul Park , Pilhan Kim , Wangyuhl Oh
IPC: C07K16/22 , A61P35/00 , A61K39/395 , A61K45/06
CPC classification number: C07K16/22 , A61P35/00 , A61K39/3955 , A61K45/06 , A61K2039/505
Abstract: The present invention relates to mouse antibodies that bind to angiopoietin-2 (Ang2), humanized anti-Ang2 antibodies derived therefrom, and the use thereof. The anti-Ang2 antibodies have a dual function of activating the Tie2 receptor together with neutralizing Ang2. The anti-Ang2 antibodies show the property of normalizing abnormal and pathological blood vessels, and thus exhibits therapeutic efficacy against various diseases and disorders associated with abnormal blood vessels. The present invention further provides an angiogenesis inhibitor and a composition for treatment of diseases associated with abnormal Ang2 expression and Tie2 dysregulation, which comprise the antibody as an active ingredient, and a composition for diagnosing diseases associated with Ang2 inhibition and Tie2 activation, which comprises the antibody.
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公开(公告)号：US12024562B2
公开(公告)日：2024-07-02
申请号：US17111413
申请日：2020-12-03
Applicant: INSTITUTE FOR BASIC SCIENCE
Inventor： Gou Young Koh , Jeomil Bae , Jaeryung Kim
IPC: C07K16/28 , A61K31/713 , A61K39/395 , A61K45/06 , A61P27/06 , C12N5/10 , C12N15/63 , A61K39/00
CPC classification number: C07K16/2863 , A61K31/713 , A61K39/3955 , A61K45/06 , A61P27/06 , C12N5/10 , C12N15/63 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/92 , C07K2317/94
Abstract: The present invention refers to an antibody against Tie-2 or antigen-binding fragment thereof, a nucleic acid encoding the same, a vector comprising the nucleic acid, a cell transformed with the vector, a manufacturing method of the antibody or antigen-binding fragment thereof, and a composition for preventing or treating angiogenic diseases, which comprises the antibody or antigen-binding fragment thereof.
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公开(公告)号：US20210179719A1
公开(公告)日：2021-06-17
申请号：US17111413
申请日：2020-12-03
Inventor： Gou Young Koh , Jeomil Bae , Jaeryung Kim
IPC: C07K16/28 , A61P27/06 , A61K45/06 , A61K39/395
Abstract: The present invention refers to an antibody against Tie-2 or antigen-binding fragment thereof, a nucleic acid encoding the same, a vector comprising the nucleic acid, a cell transformed with the vector, a manufacturing method of the antibody or antigen-binding fragment thereof, and a composition for preventing or treating angiogenic diseases, which comprises the antibody or antigen-binding fragment thereof.
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公开(公告)号：US11498962B2
公开(公告)日：2022-11-15
申请号：US16995707
申请日：2020-08-17
Inventor： Gou Young Koh , Jeomil Bae , Mi Jeong Kim , Jin-Sung Park , Su Jin Seo , Jaeryung Kim , Jang Ryul Park , Pilhan Kim , Wangyuhl Oh
IPC: A61K39/395 , C07K16/22 , A61P35/00 , A61K45/06 , A61K39/00
Abstract: The present invention relates to mouse antibodies that bind to angiopoietin-2 (Ang2), humanized anti-Ang2 antibodies derived therefrom, and the use thereof. The anti-Ang2 antibodies have a dual function of activating the Tie2 receptor together with neutralizing Ang2. The anti-Ang2 antibodies show the property of normalizing abnormal and pathological blood vessels, and thus exhibits therapeutic efficacy against various diseases and disorders associated with abnormal blood vessels. The present invention further provides an angiogenesis inhibitor and a composition for treatment of diseases associated with abnormal Ang2 expression and Tie2 dysregulation, which comprise the antibody as an active ingredient, and a composition for diagnosing diseases associated with Ang2 inhibition and Tie2 activation, which comprises the antibody.
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公开(公告)号：US20210079083A1
公开(公告)日：2021-03-18
申请号：US16995707
申请日：2020-08-17
Inventor： Gou Young Koh , Jeomil Bae , Mi Jeong Kim , Jin-Sung Park , Su Jin Seo , Jaeryung Kim , Jang Ryul Park , Pilhan Kim , Wangyuhl Oh
IPC: C07K16/22 , A61K39/395 , A61K45/06 , A61P35/00
Abstract: The present invention relates to mouse antibodies that bind to angiopoietin-2 (Ang2), humanized anti-Ang2 antibodies derived therefrom, and the use thereof. The anti-Ang2 antibodies have a dual function of activating the Tie2 receptor together with neutralizing Ang2. The anti-Ang2 antibodies show the property of normalizing abnormal and pathological blood vessels, and thus exhibits therapeutic efficacy against various diseases and disorders associated with abnormal blood vessels. The present invention provides an angiogenesis inhibitor and a composition for prevention and treatment of diseases associated with abnormal Ang2 expression and Tie2 dysregulation, which comprise the antibody as an active ingredient, and a composition for diagnosing diseases associated with Ang2 inhibition and Tie2 activation, which comprises the antibody.
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