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公开(公告)号：US20140299129A1
公开(公告)日：2014-10-09
申请号：US14312003
申请日：2014-06-23
Applicant: INO Therapeutics LLC
Inventor： Craig Flanagan , Simon Freed , John Klaus , Thomas Kohlmann , Martin D. Meglasson , Manesh Naidu , Parag Shah
CPC classification number: A61M16/0672 , A61M16/009 , A61M16/0666 , A61M16/0677 , A61M16/0875 , A61M16/10 , A61M16/1005 , A61M16/101 , A61M16/104 , A61M16/12 , A61M16/122 , A61M16/125 , A61M16/204 , A61M16/208 , A61M2016/0021 , A61M2016/0027 , A61M2202/0208 , A61M2202/0266 , A61M2202/0275 , A61M2202/0283 , A61M2205/0216 , A61M2205/3303 , A61M2205/3331 , A61M2205/75 , A61M2210/0618
Abstract: The present invention generally relates to, amongst other things, systems, devices, materials, and methods that can improve the accuracy and/or precision of nitric oxide therapy by, for example, reducing the dilution of inhaled nitric oxide (NO). As described herein, NO dilution can occur because of various factors. To reduce the dilution of an intended NO dose, various exemplary nasal cannulas, pneumatic configurations, methods of manufacturing, and methods of use, etc. are disclosed.
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公开(公告)号：US10758703B2
公开(公告)日：2020-09-01
申请号：US14886556
申请日：2015-10-19
Applicant: INO Therapeutics LLC
Inventor： Thomas Kohlmann , John Klaus
Abstract: Described are systems and methods for providing a pulse of a therapeutic gas with a desired flow profile to maximize therapeutic effectiveness. Systems and methods of the present disclosure can generate and/or provide desired flow profiles with various shapes and/or properties by configuring, modifying, optimizing, and/or factoring in aspects of at least one fixed flow rate assembly of a therapeutic gas delivery system such as, but not limited to, spatial relationships of elements of the fixed flow rate assembly, rate of valve closure and opening, latent flows, transient wave generation and/or propagation, to name a few.
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公开(公告)号：US09108016B2
公开(公告)日：2015-08-18
申请号：US14394433
申请日：2013-04-03
Applicant: INO Therapeutics LLC
Inventor： Jaron Acker , Thomas Kohlmann
CPC classification number: A61M16/202 , A61M16/0003 , A61M16/0051 , A61M16/024 , A61M16/0666 , A61M16/0677 , A61M16/12 , A61M16/20 , A61M16/204 , A61M2016/0015 , A61M2016/003 , A61M2016/0036 , A61M2202/0275 , A61M2205/14 , A61M2205/18 , A61M2205/3334 , A61M2205/50 , A61M2205/502 , A61M2205/581 , A61M2205/583 , A61M2205/6018 , A61M2205/6054 , A61M2205/6072 , A61M2202/0007
Abstract: Described are methods for safer nitric oxide delivery, as well as apparatuses for performing these methods. The methods may include detecting the presence or absence of a nasal cannula, and stopping the delivery of nitric oxide or providing an alert if the cannula is disconnected. The methods may also include purging the nasal cannula if it is reconnected after a disconnection or if it is replaced by a new cannula. Other methods pertain to automatic purging of the delivery conduit if the elapsed time between successive deliveries of therapeutic gas exceeds a predetermined period of time.
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4.发明授权公开(公告)号：US09032959B2
公开(公告)日：2015-05-19
申请号：US14096910
申请日：2013-12-04
Applicant: INO Therapeutics LLC
Inventor： Craig Flanagan , Simon Freed , John Klaus , Thomas Kohlmann , Martin D. Meglasson , Manesh Naidu , Parag Shah
CPC classification number: A61M16/0672 , A61M16/009 , A61M16/0666 , A61M16/0677 , A61M16/0875 , A61M16/10 , A61M16/1005 , A61M16/101 , A61M16/104 , A61M16/12 , A61M16/122 , A61M16/125 , A61M16/204 , A61M16/208 , A61M2016/0021 , A61M2016/0027 , A61M2202/0208 , A61M2202/0266 , A61M2202/0275 , A61M2202/0283 , A61M2205/0216 , A61M2205/3303 , A61M2205/3331 , A61M2205/75 , A61M2210/0618
Abstract: The present invention generally relates to, amongst other things, systems, devices, materials, and methods that can improve the accuracy and/or precision of nitric oxide therapy by, for example, reducing the dilution of inhaled nitric oxide (NO). As described herein, NO dilution can occur because of various factors. To reduce the dilution of an intended NO dose, various exemplary nasal cannulas, pneumatic configurations, methods of manufacturing, and methods of use, etc. are disclosed.
Abstract translation: 本发明通常涉及通过例如减少吸入的一氧化氮（NO）的稀释度来提供一氧化氮治疗的精度和/或精度的系统，装置，材料和方法。 如本文所述，由于各种因素，可能会发生NO稀释。 为了减少预期的NO剂量的稀释，公开了各种示例性鼻插管，气动构造，制造方法和使用方法等。
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公开(公告)号：US20150352311A1
公开(公告)日：2015-12-10
申请号：US14827523
申请日：2015-08-17
Applicant: INO Therapeutics LLC
Inventor： Jaron M. Acker , Thomas Kohlmann
CPC classification number: A61M16/202 , A61M16/0003 , A61M16/0051 , A61M16/024 , A61M16/0666 , A61M16/0677 , A61M16/12 , A61M16/20 , A61M16/204 , A61M2016/0015 , A61M2016/003 , A61M2016/0036 , A61M2202/0275 , A61M2205/14 , A61M2205/18 , A61M2205/3334 , A61M2205/50 , A61M2205/502 , A61M2205/581 , A61M2205/583 , A61M2205/6018 , A61M2205/6054 , A61M2205/6072 , A61M2202/0007
Abstract: Described are methods for safer nitric oxide delivery, as well as apparatuses for performing these methods. The methods may include detecting the presence or absence of a nasal cannula, and stopping the delivery of nitric oxide or providing an alert if the cannula is disconnected. The methods may also include purging the nasal cannula if it is reconnected after a disconnection or if it is replaced by a new cannula. Other methods pertain to automatic purging of the delivery conduit if the elapsed time between successive deliveries of therapeutic gas exceeds a predetermined period of time.
Abstract translation: 描述了用于更安全的一氧化氮递送的方法以及用于执行这些方法的装置。 所述方法可以包括检测鼻插管的存在或不存在，以及如果插管断开，则停止一氧化氮的输送或提供警报。 所述方法还可以包括如果在断开连接之后重新连接或者如果它被新的插管替代，则清洗鼻插管。 如果治疗气体的连续输送之间的经过时间超过预定时间段，则其它方法涉及自动清除输送管道。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20150238720A1
公开(公告)日：2015-08-27
申请号：US14706449
申请日：2015-05-07
Applicant: INO Therapeutics LLC
Inventor： Craig Flanagan , Simon Freed , John Klaus , Thomas Kohlmann , Martin D. Meglasson , Manesh Naidu , Parag Shah
CPC classification number: A61M16/0672 , A61M16/009 , A61M16/0666 , A61M16/0677 , A61M16/0875 , A61M16/10 , A61M16/1005 , A61M16/101 , A61M16/104 , A61M16/12 , A61M16/122 , A61M16/125 , A61M16/204 , A61M16/208 , A61M2016/0021 , A61M2016/0027 , A61M2202/0208 , A61M2202/0266 , A61M2202/0275 , A61M2202/0283 , A61M2205/0216 , A61M2205/3303 , A61M2205/3331 , A61M2205/75 , A61M2210/0618
Abstract: The present invention generally relates to, amongst other things, systems, devices, materials, and methods that can improve the accuracy and/or precision of nitric oxide therapy by, for example, reducing the dilution of inhaled nitric oxide (NO). As described herein, NO dilution can occur because of various factors. To reduce the dilution of an intended NO dose, various exemplary nasal cannulas, pneumatic configurations, methods of manufacturing, and methods of use, etc. are disclosed.
Abstract translation: 本发明通常涉及通过例如减少吸入的一氧化氮（NO）的稀释度来提供一氧化氮治疗的精度和/或精度的系统，装置，材料和方法。 如本文所述，由于各种因素，可能会发生NO稀释。 为了减少预期的NO剂量的稀释，公开了各种示例性鼻插管，气动构造，制造方法和使用方法等。
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公开(公告)号：US20140283828A1
公开(公告)日：2014-09-25
申请号：US14211919
申请日：2014-03-14
Applicant: INO Therapeutics LLC
Inventor： Jaron Acker , Thomas Kohlmann , Craig R. Tolmie
CPC classification number: A61M16/203 , A61M16/0003 , A61M16/0051 , A61M16/0057 , A61M16/024 , A61M16/04 , A61M16/0666 , A61M16/0672 , A61M16/104 , A61M16/12 , A61M2016/0018 , A61M2016/0027 , A61M2202/0233 , A61M2202/0275 , A61M2205/3334 , A61M2202/0007
Abstract: Described are methods and devices for therapeutic or medical gas delivery that utilize at least one proportional control valve and at least one binary control valve. The proportional control valve may be in series with the binary control valve to provide a valve combination capable of pulsing therapeutic gas at different flow rates, depending on the setting of the proportional control valve. Alternatively, the proportional control valve and binary control valve may be in parallel flow paths.
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8.发明申请公开(公告)号：US20140158121A1
公开(公告)日：2014-06-12
申请号：US14096910
申请日：2013-12-04
Applicant: INO Therapeutics LLC
Inventor： Craig Flanagan , Simon Freed , John Klaus , Thomas Kohlmann , Martin D. Meglasson , Manesh Naidu , Parag Shah
IPC: A61M16/12
CPC classification number: A61M16/0672 , A61M16/009 , A61M16/0666 , A61M16/0677 , A61M16/0875 , A61M16/10 , A61M16/1005 , A61M16/101 , A61M16/104 , A61M16/12 , A61M16/122 , A61M16/125 , A61M16/204 , A61M16/208 , A61M2016/0021 , A61M2016/0027 , A61M2202/0208 , A61M2202/0266 , A61M2202/0275 , A61M2202/0283 , A61M2205/0216 , A61M2205/3303 , A61M2205/3331 , A61M2205/75 , A61M2210/0618
Abstract: The present invention generally relates to, amongst other things, systems, devices, materials, and methods that can improve the accuracy and/or precision of nitric oxide therapy by, for example, reducing the dilution of inhaled nitric oxide (NO). As described herein, NO dilution can occur because of various factors. To reduce the dilution of an intended NO dose, various exemplary nasal cannulas, pneumatic configurations, methods of manufacturing, and methods of use, etc. are disclosed.
Abstract translation: 本发明通常涉及通过例如减少吸入的一氧化氮（NO）的稀释度来提供一氧化氮治疗的精度和/或精度的系统，装置，材料和方法。 如本文所述，由于各种因素，可能会发生NO稀释。 为了减少预期的NO剂量的稀释，公开了各种示例性鼻插管，气动构造，制造方法和使用方法等。
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公开(公告)号：US20140150789A1
公开(公告)日：2014-06-05
申请号：US14096629
申请日：2013-12-04
Applicant: INO Therapeutics LLC
Inventor： Craig Flanagan , Simon Freed , John Klaus , Thomas Kohlmann , Martin D. Meglasson , Manesh Naidu , Parag Shah
CPC classification number: A61M16/0672 , A61M16/009 , A61M16/0666 , A61M16/0677 , A61M16/0875 , A61M16/10 , A61M16/1005 , A61M16/101 , A61M16/104 , A61M16/12 , A61M16/122 , A61M16/125 , A61M16/204 , A61M16/208 , A61M2016/0021 , A61M2016/0027 , A61M2202/0208 , A61M2202/0266 , A61M2202/0275 , A61M2202/0283 , A61M2205/0216 , A61M2205/3303 , A61M2205/3331 , A61M2205/75 , A61M2210/0618
Abstract: The present invention generally relates to, amongst other things, systems, devices, materials, and methods that can improve the accuracy and/or precision of nitric oxide therapy by, for example, reducing the dilution of inhaled nitric oxide (NO). As described herein, NO dilution can occur because of various factors. To reduce the dilution of an intended NO dose, various exemplary nasal cannulas, pneumatic configurations, methods of manufacturing, and methods of use, etc. are disclosed.
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公开(公告)号：US09616193B2
公开(公告)日：2017-04-11
申请号：US14211919
申请日：2014-03-14
Applicant: INO Therapeutics LLC
Inventor： Jaron Acker , Thomas Kohlmann , Craig R. Tolmie
CPC classification number: A61M16/203 , A61M16/0003 , A61M16/0051 , A61M16/0057 , A61M16/024 , A61M16/04 , A61M16/0666 , A61M16/0672 , A61M16/104 , A61M16/12 , A61M2016/0018 , A61M2016/0027 , A61M2202/0233 , A61M2202/0275 , A61M2205/3334 , A61M2202/0007
Abstract: Described are methods and devices for therapeutic or medical gas delivery that utilize at least one proportional control valve and at least one binary control valve. The proportional control valve may be in series with the binary control valve to provide a valve combination capable of pulsing therapeutic gas at different flow rates, depending on the setting of the proportional control valve. Alternatively, the proportional control valve and binary control valve may be in parallel flow paths.
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