公开(公告)号：US12053525B2

公开(公告)日：2024-08-06

申请号：US17395400

申请日：2021-08-05

Applicant: Genentech, Inc.

Inventor： Paul Carter ,  Christoph Spiess ,  Yiyuan Yin ,  Jianhui Zhou ,  Wendy Sandoval ,  Jacob Corn ,  Michael Dillon

IPC: C07H21/04 ,  A61K39/395 ,  A61K39/44 ,  C07K16/46 ,  G16B20/30 ,  G16B20/50 ,  A61K39/00 ,  G01N33/68 ,  G16B5/00 ,  G16B20/00

CPC classification number: A61K39/44 ,  A61K39/39558 ,  C07K16/468 ,  G16B20/30 ,  G16B20/50 ,  A61K39/3955 ,  A61K39/39566 ,  A61K2039/507 ,  C07K2317/31 ,  C07K2317/522 ,  C07K2317/56 ,  G01N33/6848 ,  G16B5/00 ,  G16B20/00

Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

公开(公告)号：US11116840B2

公开(公告)日：2021-09-14

申请号：US15789670

申请日：2017-10-20

Applicant: Genentech, Inc.

Inventor： Paul Carter ,  Christoph Spiess ,  Yiyuan Yin ,  Jianhui Zhou ,  Wendy Sandoval ,  Jacob Corn ,  Michael Dillon

IPC: A61K39/44 ,  C07K16/46 ,  A61K39/395 ,  G16B5/00 ,  G16B20/00 ,  A61K39/00 ,  G01N33/68

Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

公开(公告)号：US10208120B2

公开(公告)日：2019-02-19

申请号：US14934059

申请日：2015-11-05

Applicant: Genentech, Inc.

Inventor： Yiyuan Yin ,  Avi Ashkenazi ,  Paul J. Carter ,  Mark Chen ,  Junichiro Sonoda

IPC: A61K39/00 ,  C07K16/28 ,  C07K16/30 ,  C07K16/40 ,  C12P21/02

Abstract: The invention provides dual specific anti-FGFR2 and FGFR3 (FGFR2/3) antibodies, and compositions comprising and methods of using these antibodies.

公开(公告)号：US20220056134A1

公开(公告)日：2022-02-24

申请号：US17454015

申请日：2021-11-08

Applicant: Genentech, Inc.

Inventor： Kamal Kishore JOSHI ,  Paul J. Carter ,  Yiyuan Yin

IPC: C07K16/28 ,  C12N5/10

Abstract: Provided are, inter alia, methods of improving pairing of a heavy chain and a light chain of an antibody (such as a bispecific antibody). Also provided are antibodies (e.g., bispecific antibodies) generated using such methods, libraries, and methods of screening such libraries.