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公开(公告)号：US11008312B2
公开(公告)日：2021-05-18
申请号：US16398795
申请日：2019-04-30
Applicant: Genentech, Inc.
Inventor： Sarah M. Bronner , James J. Crawford , Andrew Cridland , Patrick Cyr , Benjamin Fauber , Emanuela Gancia , Alberto Gobbi , Christopher Hurley , Jonathan Killen , Wendy Lee , Olivier Rene , Monique Bodil Van Niel , Stuart Ward , Paul Winship , Jason Zbieg
IPC: C07D413/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D401/14
Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein m, n, p, q A, B, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
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公开(公告)号：US20190152949A1
公开(公告)日：2019-05-23
申请号：US16198597
申请日：2018-11-21
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Patrick Cyr , Sarah Bronner , F. Anthony Romero , Steven Magnuson , Vickie Hsiao-Wei Tsui , John Wai , Kwong Wah Lai , Fei Wang
IPC: C07D401/14 , A61K45/06 , A61K31/5513 , A61K31/4375 , A61K31/435 , A61K31/437 , C07D471/04 , C07D413/14 , C07D417/14 , A61K31/5377 , A61K31/519 , C07D487/22 , A61K31/4985 , A61K31/5025 , A61K31/496 , C07D405/14 , C07D409/14
Abstract: The present invention relates to compounds of formula (I) and formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R5-R6 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II), or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
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公开(公告)号：US20220127265A1
公开(公告)日：2022-04-28
申请号：US17570139
申请日：2022-01-06
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Patrick Cyr , Sarah Bronner , F. Anthony Romero , Steven Magnuson , Vickie Hsiao-Wei Tsui , Jeremy M. Murray , John Wai , Kwong Wah Lai , Fei Wang , Kevin X. Chen
IPC: C07D471/04 , C07D519/00
Abstract: The present invention relates to a compound formula (I): and to salts thereof, wherein R1, R2 X, and Y have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
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公开(公告)号：US20190263794A1
公开(公告)日：2019-08-29
申请号：US16398795
申请日：2019-04-30
Applicant: Genentech, Inc.
Inventor： Sarah M. Bronner , James J. Crawford , Andrew Cridland , Patrick Cyr , Benjamin Fauber , Emanuela Gancia , Alberto Gobbi , Christopher Hurley , Jonathan Killen , Wendy Lee , Olivier Rene , Monique Bodil Van Niel , Stuart Ward , Paul Winship , Jason Zbieg
IPC: C07D413/14 , C07D403/14 , C07D405/14
Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein m, n, p, q A, B, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
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公开(公告)号：US20190241558A1
公开(公告)日：2019-08-08
申请号：US16198581
申请日：2018-11-21
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Patrick Cyr , Sarah Bronner , F. Anthony Romero , Steven Magnuson , Vickie Hsiao-Wei Tsui , Jeremy M. Murray , John Wai , Kwong Wah Lai , Fei Wang , Kevin X. Chen
IPC: C07D471/04
CPC classification number: C07D471/04 , C07D519/00
Abstract: The present invention relates to a compound formula (I): and to salts thereof, wherein R1, R2 X, and Y have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
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Patent Agency Ranking
公开(公告)号：US09763922B2
公开(公告)日：2017-09-19
申请号：US14952821
申请日：2015-11-25
Applicant: Genentech, Inc. , Constellation Pharmaceuticals, Inc.
Inventor： Marc Adler , Brian K. Albrecht , Sarah Bronner , Kevin X. Chen , Alexandre Côté , Terry Crawford , Patrick Cyr , Jackson Egen , Steven Kauder , Kwong Wah Lai , Jiangpeng Liao , Steven Magnuson , Jeremy Murray , Richard Pastor , F. Anthony Romero , Alexander M. Taylor , Vickie Hsiao-Wei Tsui , Fei Wang , Bing-Yan Zhu
IPC: A61K31/437 , A61K31/4375 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5415 , A61K31/55 , C07D471/04 , C07D519/00 , A61K45/06
CPC classification number: A61K31/437 , A61K31/4375 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07D471/04 , C07D519/00
Abstract: The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
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公开(公告)号：US11247989B2
公开(公告)日：2022-02-15
申请号：US16198581
申请日：2018-11-21
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Patrick Cyr , Sarah Bronner , F. Anthony Romero , Steven Magnuson , Vickie Hsiao-Wei Tsui , Jeremy M. Murray , John Wai , Kwong Wah Lai , Fei Wang , Kevin X. Chen
IPC: C07D471/04 , C07D519/00
Abstract: The present invention relates to a compound formula (I): and to salts thereof, wherein R1, R2 X, and Y have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
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公开(公告)号：US11168070B2
公开(公告)日：2021-11-09
申请号：US16886541
申请日：2020-05-28
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Patrick Cyr , Sarah Bronner , F. Anthony Romero , Steven Magnuson , Vickie Hsiao-Wei Tsui , John Wai , Kwong Wah Lai , Fei Wang
IPC: C07D401/04 , A61K31/47 , A61P25/00 , C07D401/14 , C07D405/14 , C07D413/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D243/14 , C07D413/04 , C07D267/14 , C07D413/10 , A61K31/435 , A61K31/437 , A61K31/4375 , A61K31/496 , A61K31/4985 , A61K31/5025 , A61K31/519 , A61K31/5377 , A61K31/5513 , A61K45/06 , C07D487/22
Abstract: The present invention relates to compounds of formula (I) and formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R5-R6 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II), or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
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公开(公告)号：US10696655B2
公开(公告)日：2020-06-30
申请号：US16198597
申请日：2018-11-21
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Patrick Cyr , Sarah Bronner , F. Anthony Romero , Steven Magnuson , Vickie Hsiao-Wei Tsui , John Wai , Kwong Wah Lai , Fei Wang
IPC: C07D223/16 , C07D243/12 , C07D243/14 , C07D267/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D417/14 , C07D401/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D413/10 , A61K31/435 , A61K31/437 , A61K31/4375 , A61K31/496 , A61K31/4985 , A61K31/5025 , A61K31/519 , A61K31/5377 , A61K31/5513 , A61K45/06 , C07D487/22
Abstract: The present invention relates to compounds of formula (I) and formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R5-R6 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II), or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
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公开(公告)号：US20170333406A1
公开(公告)日：2017-11-23
申请号：US15667227
申请日：2017-08-02
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Marc Adler , Brian K. Albrecht , Sarah Bronner , Kevin X. Chen , Alexandre Côté , Terry Crawford , Patrick Cyr , Jackson Egen , Steven Kauder , Kwong Wah Lai , Jiangpeng Liao , Steven Magnuson , Jeremy Murray , Richard Pastor , F. Anthony Romero , Alexander M. Taylor , Vickie Hsiao-Wei Tsui , Fei Wang , Bing-Yan Zhu
IPC: A61K31/437 , C07D471/04 , A61K45/06 , A61K31/55 , A61K31/5415 , A61K31/5377 , A61K31/4375 , A61K31/506 , A61K31/498 , A61K31/496 , A61K31/4725 , A61K31/4709 , C07D519/00 , A61K31/538
CPC classification number: A61K31/437 , A61K31/4375 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07D471/04 , C07D519/00
Abstract: The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
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