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公开(公告)号：US09884126B2
公开(公告)日：2018-02-06
申请号：US14284619
申请日：2014-05-22
Applicant: Genentech, Inc.
Inventor： Eric J. Brown , John Flygare , Wouter Hazenbos , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC: A61K47/48 , C07K16/12 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , A61K31/4709 , A61K31/7048 , A61K31/7056 , A61K38/12
CPC classification number: A61K47/6849 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , A61K31/4709 , A61K31/7048 , A61K31/7056 , A61K38/12 , A61K47/6801 , A61K47/6803 , A61K47/6809 , A61K47/6835 , A61K47/6851 , C07K16/1271 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
Abstract: The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
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公开(公告)号：US09999681B2
公开(公告)日：2018-06-19
申请号：US15181825
申请日：2016-06-14
Applicant: Genentech, Inc.
Inventor： John Flygare , Janet Gunzner-Toste , Thomas Pillow , Brian Safina , Vishal Verma , Binqing Wei , Guiling Zhao , Leanna Staben
CPC classification number: A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K47/6851 , A61K47/6889 , C07K16/28 , C07K16/2851 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/76
Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.
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公开(公告)号：US20180016325A1
公开(公告)日：2018-01-18
申请号：US15718876
申请日：2017-09-28
Applicant: Genentech, Inc.
Inventor： Eric J. Brown , Martine Darwish , John Flygare , Wouter Hazenbos , Byoung Chul Lee , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC: C07K16/12 , A61K45/06 , A61K39/40 , A61K31/4025 , A61K31/5386
CPC classification number: C07K16/1271 , A61K31/4025 , A61K31/5386 , A61K39/40 , A61K45/06 , A61K47/6809 , A61K47/6835 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
Abstract: The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
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公开(公告)号：US20160074529A1
公开(公告)日：2016-03-17
申请号：US14945716
申请日：2015-11-19
Applicant: GENENTECH, INC.
Inventor： Eric J. Brown , John Flygare , Wouter Hazenbos , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC: A61K47/48 , A61K31/7048 , A61K31/4709 , A61K38/12 , A61K31/4375 , A61K31/4436 , A61K31/7056 , A61K31/439
CPC classification number: A61K47/6849 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , A61K31/4709 , A61K31/7048 , A61K31/7056 , A61K38/12 , A61K47/6801 , A61K47/6803 , A61K47/6809 , A61K47/6835 , A61K47/6851 , C07K16/1271 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
Abstract: The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
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![1-(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE DIMER ANTIBODY-DRUG CONJUGATE COMPOUNDS, AND METHODS OF USE AND TREATMENT](/abs-image/US/2015/06/18/US20150165063A1/abs.jpg.150x150.jpg)
5.发明申请1-(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE DIMER ANTIBODY-DRUG CONJUGATE COMPOUNDS, AND METHODS OF USE AND TREATMENT 审中-公开1-（氯代乙基）-2,3-二氢-1H-苯并[E]吲哚类抗生素联合化合物，以及使用和治疗方法公开(公告)号：US20150165063A1
公开(公告)日：2015-06-18
申请号：US14305643
申请日：2014-06-16
Applicant: Genentech, Inc.
Inventor： John Flygare , Thomas Pillow , Brian Safina , Vishal Verma , Binqing Wei , William Denny , Anna Giddens , Ho Lee , Guo-Liang Lu , Christian Miller , Gordon Rewcastle , Moana Tercel , Muriel Bonnet
IPC: A61K47/48 , C07K16/18 , C07K16/32 , C07D401/14 , C07K5/062 , C07F9/6558 , C07D403/14 , C07H15/24 , C07K16/28 , C07D209/62
Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.
Abstract translation: 本发明提供包含通过接头与1-（氯甲基）-2,3-二氢-1H-苯并[e]吲哚（CBI）二烯体（CBI）二聚体药物部分缀合的抗体的抗体 - 药物偶联物，以及使用抗体药物 共轭物
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Patent Agency Ranking
公开(公告)号：US10570192B2
公开(公告)日：2020-02-25
申请号：US15718876
申请日：2017-09-28
Applicant: Genentech, Inc.
Inventor： Eric J. Brown , Martine Darwish , John Flygare , Wouter Hazenbos , Byoung Chul Lee , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC: C07K16/12 , A61K39/40 , A61K31/5386 , A61K45/06 , A61K31/4025 , A61K47/68
Abstract: The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
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公开(公告)号：US10533058B2
公开(公告)日：2020-01-14
申请号：US15104388
申请日：2014-12-16
Applicant: GENENTECH INC. , MEDIMMUNE LIMITED
Inventor： John Flygare , Janet Gunzner-Toste , Thomas Pillow , Brian Safina , Vishal Verma , Binqing Wei , Guiling Zhao , Leanna Staben , Philip Wilson Howard , Luke Masterson
IPC: A61K47/68 , A61K31/5517 , C07K16/30 , C07K16/28
Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, pharmaceutical compositions containing them, and to their use in therapy for the prevention treatment of cancer.
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公开(公告)号：US20150366985A1
公开(公告)日：2015-12-24
申请号：US14284619
申请日：2014-05-22
Applicant: GENENTECH, INC.
Inventor： Eric J. Brown , John Flygare , Wouter Hazenbos , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC: A61K47/48 , A61K31/395
CPC classification number: A61K47/6849 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , A61K31/4709 , A61K31/7048 , A61K31/7056 , A61K38/12 , A61K47/6801 , A61K47/6803 , A61K47/6809 , A61K47/6835 , A61K47/6851 , C07K16/1271 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
Abstract: The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
Abstract translation: 本发明提供了抗壁磷壁酸抗体及其抗生素缀合物及其使用方法。
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公开(公告)号：US20140356375A1
公开(公告)日：2014-12-04
申请号：US14284609
申请日：2014-05-22
Applicant: GENENTECH, INC.
Inventor： Eric J. Brown , Martine Darwish , John Flygare , Wouter Hazenbos , Byoung Chul Lee , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC: C07K16/12 , A61K39/40 , A61K31/5383 , A61K47/48
CPC classification number: C07K16/1271 , A61K31/5383 , A61K47/6809 , A61K47/6835 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
Abstract: The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
Abstract translation: 本发明提供了抗壁磷壁酸抗体及其抗生素缀合物及其使用方法。
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公开(公告)号：US11692043B2
公开(公告)日：2023-07-04
申请号：US16696455
申请日：2019-11-26
Applicant: GENENTECH INC. , MEDIMMUNE LIMITED
Inventor： John Flygare , Janet Gunzner-Toste , Thomas Pillow , Brian Safina , Vishal Verma , Binqing Wei , Guiling Zhao , Leanna Staben , Philip Wilson Howard , Luke Masterson
IPC: C07K16/30 , A61K47/68 , A61K31/5517 , C07K16/28
CPC classification number: C07K16/3092 , A61K31/5517 , A61K47/6803 , A61K47/6851 , A61K47/6867 , A61K47/6869 , A61K47/6889 , C07K16/2851 , C07K16/30 , C07K16/3061 , C07K16/3069 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56
Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof pharmaceutical compositions containing them, and to their use in therapy for the prevention treatment of cancer.
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