公开(公告)号：US20230210926A1

公开(公告)日：2023-07-06

申请号：US18066814

申请日：2022-12-15

Applicant: California Institute of Technology

Inventor： Marjorie T. Buss ,  Robert C. Hurt ,  Katie K. Wong ,  Mikhail G. Shapiro ,  Mengtong Duan ,  Arash Farhadi ,  Mei Yi You

IPC: A61K35/748 ,  C07K14/195 ,  A61K49/22 ,  A61P35/00

CPC classification number: A61K35/748 ,  A61K49/22 ,  A61P35/00 ,  C07K14/195 ,  A61K2035/115

Abstract: Disclosed herein include methods, compositions, and kits suitable for use in dynamic non-destructive imaging. The non-destructive imaging can be nonlinear ultrasound imaging. There are provided, in some embodiments, nucleic acid compositions encoding gas vesicles (GVs) capable of producing nonlinear ultrasound contrast upon expression in a prokaryotic cell (e.g., a probiotic bacterial cell) or a eukaryotic cell (e.g., a therapeutic mammalian cell).