公开(公告)号：US11911477B2

公开(公告)日：2024-02-27

申请号：US17646935

申请日：2022-01-04

申请人： Beihang University

发明人： Bing Zhou ,  Xunming Ji ,  Jing Liang ,  Panpan Yu ,  Rongrong Han

IPC分类号： A61K47/36 ,  A61P25/00 ,  A61K45/06

CPC分类号： A61K47/36 ,  A61K45/06 ,  A61P25/00

摘要： The present disclosure provides use of fructose in preparing a drug for treating a cerebral ischemic stroke, and relates to the technical field of biomedicine. In the present disclosure, an ischemic injury cell model and an ischemic injury animal model are established, and fructose treatment is conducted on the injury models; and it is found that the fructose can regulate energy metabolism and redox metabolism of neurons, and reduce an ischemic injury of model cells and model animals. Specifically, the present disclosure includes: reducing a neuronal mortality after the ischemic injury, reducing an area of cerebral infarction in animals with the ischemic injury, and improving neurobehavioral characteristics of the animals.