公开(公告)号：US10465009B2

公开(公告)日：2019-11-05

申请号：US14649469

申请日：2013-12-05

Applicant: Amgen Inc.

Inventor： Richard J. Armitage ,  Michelle Blake ,  William C. Fanslow, III ,  Jason Charles O'Neill ,  Gunasekaran Kannan ,  Jiangchun Xu ,  Mark Edward Tometsko ,  Zhulun Wang ,  Athena Sudom

IPC: C07K16/28 ,  A61K47/48 ,  A61K45/06 ,  A61N5/10 ,  A61K47/68 ,  A61K39/00

Abstract: The present invention relates to BCMA (B-Cell Maturation Antigen) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases. The present invention also relates to BCMA antibody drug conjugates and uses thereof.

公开(公告)号：US10220090B2

公开(公告)日：2019-03-05

申请号：US14967167

申请日：2015-12-11

Applicant: Amgen Inc.

Inventor： Richard J. Armitage ,  Michelle Blake ,  William C. Fanslow, III ,  Jason Charles O'Neill ,  Gunasekaran Kannan ,  Jiangchun Xu ,  Mark Edward Tometsko

IPC: C07K16/18 ,  A61K45/06 ,  A61K39/00 ,  C07K16/28 ,  A61K39/395 ,  A61K31/395 ,  A61K47/68

Abstract: The present invention relates to BCMA (B-Cell Maturation Antigen) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases. The present invention also relates to BCMA antibody drug conjugates.

公开(公告)号：US09243058B2

公开(公告)日：2016-01-26

申请号：US14098275

申请日：2013-12-05

Applicant: Amgen Inc.

Inventor： Richard J. Armitage ,  Michelle Blake ,  William C. Fanslow, III ,  Jason Charles O'Neill ,  Gunasekaran Kannan ,  Jiangchun Xu ,  Mark Edward Tometsko

IPC: C07K16/18 ,  A61K45/06 ,  A61K47/48 ,  C07K16/28 ,  A61K39/00

CPC classification number: A61K39/3955 ,  A61K31/395 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6867 ,  A61K2039/505 ,  A61K2039/572 ,  C07K16/18 ,  C07K16/2878 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention relates to BCMA (B-Cell Maturation Antigen) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases. The present invention also relates to BCMA antibody drug conjugates.

Abstract translation: 本发明涉及BCMA（B细胞成熟抗原）抗原结合蛋白，例如抗体，编码所述抗原结合蛋白的多核苷酸序列，以及用于诊断和治疗疾病的组合物和方法。 本发明还涉及BCMA抗体药物偶联物。