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公开(公告)号：US11513257B2
公开(公告)日：2022-11-29
申请号：US17122109
申请日：2020-12-15
Applicant: Alcon Inc.
Inventor： Ying Zheng , Jang-Shing Chiou , Jinbo Dou , Yuan Chang , Junhao Ge , Steve Yun Zhang , Li Yao , Karen Belinda Sentell , Ye Hong
Abstract: The invention relates to an ophthalmic product which comprises a sealed and autoclave-sterilized lens package including (1) a post-autoclave packaging solution containing a polymeric surfactant having an HLB value of from about 11 to about 16 and a Mn of from about 800 to about 20,000 Daltons and (2) a readily-usable silicone hydrogel (SiHy) contact lens immersed in the packaging solution. The readily-usable SiHy contact lens comprises the polymeric surfactant thereon providing an excellent wettability to the readily-usable SiHy contact lens directly out of the lens package, and also the leachable polymeric surfactant which is physically distributed in the polymer matrix of the SiHy contact lens and can be released to the eye of a patient for at least 7 days of daily wear and to replenish the lens surface-bound polymeric surfactant to provide sustainable wettabilities to the contact lens and the eye.
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公开(公告)号：US20210181379A1
公开(公告)日：2021-06-17
申请号：US17122109
申请日：2020-12-15
Applicant: Alcon Inc.
Inventor： Ying Zheng , Jang-Shing Chiou , Jinbo Dou , Yuan Chang , Junhao Ge , Steve Yun Zhang , Li Yao , Karen Belinda Sentell , Ye Hong
Abstract: The invention relates to an ophthalmic product which comprises a sealed and autoclave-sterilized lens package including (1) a post-autoclave packaging solution containing a polymeric surfactant having an HLB value of from about 11 to about 16 and a Mn of from about 800 to about 20,000 Daltons and (2) a readily-usable silicone hydrogel (SiHy) contact lens immersed in the packaging solution. The readily-usable SiHy contact lens comprises the polymeric surfactant thereon providing an excellent wettability to the readily-usable SiHy contact lens directly out of the lens package, and also the leachable polymeric surfactant which is physically distributed in the polymer matrix of the SiHy contact lens and can be released to the eye of a patient for at least 7 days of daily wear and to replenish the lens surface-bound polymeric surfactant to provide sustainable wettabilities to the contact lens and the eye.
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公开(公告)号：US11927512B2
公开(公告)日：2024-03-12
申请号：US17087983
申请日：2020-11-03
Applicant: Alcon Inc.
Inventor： Yuan Chang , Ying Zheng , Junhao Ge , Steve Yun Zhang , Karen Belinda Sentell , Jinbo Dou
CPC classification number: G01N1/30 , G01N1/04 , G01N21/77 , G02B1/043 , G01N2001/302 , G01N2021/7786
Abstract: The invention provides a method for imaging and thickness determination of coatings on coated contact lenses. The method comprises selectively staining a negatively-charged-groups-containing coating over the lens body of a coated contact lens by immersing the coated contact lens in an aqueous solution comprising a fluorescently-labeled polycationic polymer and having a pH of from about 6.5 to 8.0; orthogonally cutting the selectively-stained coated contact lens; and determining the thickness of the coating on the coated contact lens. In addition, the invention provides a method for selecting a candidate coating material comprising negatively charged groups for applying a coating with a desired thickness onto silicone hydrogel contact lenses and for optimizing a coating process for producing coated silicone hydrogel contact lenses with a desired thickness coating thereon.
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公开(公告)号：US20210131923A1
公开(公告)日：2021-05-06
申请号：US17087983
申请日：2020-11-03
Applicant: Alcon Inc.
Inventor： Yuan Chang , Ying Zheng , Junhao Ge , Steve Yun Zhang , Karen Belinda Sentell , Jinbo Dou
Abstract: The invention provides a method for imaging and thickness determination of coatings on coated contact lenses. The method comprises selectively staining a negatively-charged-groups-containing coating over the lens body of a coated contact lens by immersing the coated contact lens in an aqueous solution comprising a fluorescently-labeled polycationic polymer and having a pH of from about 6.5 to 8.0; orthogonally cutting the selectively-stained coated contact lens; and determining the thickness of the coating on the coated contact lens. In addition, the invention provides a method for selecting a candidate coating material comprising negatively charged groups for applying a coating with a desired thickness onto silicone hydrogel contact lenses and for optimizing a coating process for producing coated silicone hydrogel contact lenses with a desired thickness coating thereon.
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