-
![PROCESS FOR RACEMIZING AND ISOLATING ATROPISOMERS OF 7-CHLORO-6-FLUORO-1-(2-ISOPROPYL-4-METHYLPYRIDIN-3-YL)PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE](/abs-image/US/2023/12/07/US20230391771A1/abs.jpg.150x150.jpg)
公开(公告)号：US20230391771A1
公开(公告)日：2023-12-07
申请号：US18030685
申请日：2021-10-06
Applicant: AMGEN INC.
Inventor： Matthew G. BEAVER , Michael T. CORBETT , Yuanqing FANG , David D. FORD , Andrew T. PARSONS , Gabrielle ST-PIERRE , Reem TELMESANI
IPC: C07D471/04
CPC classification number: C07D471/04 , C07B2200/13 , C07B2200/07
Abstract: Provided herein is a process comprising heating a composition comprising (P)-compound A or a salt thereof and a solvent to a temperature of 250° C. to 350° C. to form racemized compound A. Also provided is a process for isolating (P)-compound A from a composition comprising (P)-compound A and a tartrate, as described herein. Further provided herein, is a process for isolating a free acid of a tartrate or a hydrate thereof from a composition comprising a tartrate, (P)-compound A, and an organic solvent.
-
公开(公告)号：US20160264526A1
公开(公告)日：2016-09-15
申请号：US15163186
申请日：2016-05-24
Applicant: AMGEN INC.
Inventor： Matthew BIO , Sebastien CAILLE , Brian COCHRAN , Yuanqing FANG , Filisaty VOUNATSOS , Sarah WORTMAN
IPC: C07D211/76
CPC classification number: A61K31/451 , C07B2200/13 , C07C309/04 , C07C309/25 , C07C309/35 , C07C313/02 , C07D211/76 , C07D211/94 , C07D491/048 , C07D498/04
Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
Abstract translation: 本发明提供了制备2 - （（3R，5R，6S）-5-（3-氯苯基）-6-（4-氯苯基）-1 - （（S）-1-（异丙基磺酰基）-3-甲基丁基 -2-基）-3-甲基-2-氧代哌啶-3-基）乙酸，以及制备中间体的中间体和方法。 还提供了化合物和中间体的晶型。
-
![PROCESS FOR RACEMIZING AND ISOLATING ATROPISOMERS OF 7-CHLORO-6-FLUORO-1-(2-ISOPROPYL-4-METHYLPYRIDIN-3-YL)PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE](/abs-image/US/2025/04/17/US20250122197A1/abs.jpg.150x150.jpg)
公开(公告)号：US20250122197A1
公开(公告)日：2025-04-17
申请号：US18987607
申请日：2024-12-19
Applicant: AMGEN INC.
Inventor： Matthew G. BEAVER , Michael T. CORBETT , Yuanqing FANG , David D. FORD , Andrew T. PARSONS , Gabrielle ST-PIERRE , Reem TELMESANI
IPC: C07D471/04
Abstract: Provided herein is a process comprising heating a composition comprising (P)-compound A or a salt thereof and a solvent to a temperature of 250° C. to 350° C. to form racemized compound A. Also provided is a process for isolating (P)-compound A from a composition comprising (P)-compound A and a tartrate, as described herein. Further provided herein, is a process for isolating a free acid of a tartrate or a hydrate thereof from a composition comprising a tartrate, (P)-compound A, and an organic solvent.
-
公开(公告)号：US20220280496A1
公开(公告)日：2022-09-08
申请号：US17500039
申请日：2021-10-13
Applicant: AMGEN INC.
Inventor： Matthew BIO , Sebastien CAILLE , Brian COCHRAN , Yuanqing FANG , Brian M. FOX , Brian S. LUCAS , Lawrence R. MCGEE , Filisaty VOUNATSOS , Sean H. WIEDEMANN , Sarah WORTMAN
IPC: A61K31/451 , C07D211/94 , C07D491/048 , C07C309/25 , C07C309/04 , C07C313/02 , C07C309/35 , C07D498/04 , C07D211/76
Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
-
公开(公告)号：US20230301974A1
公开(公告)日：2023-09-28
申请号：US18313428
申请日：2023-05-08
Applicant: AMGEN INC.
Inventor： Matthew BIO , Sebastien CAILLE , Brian COCHRAN , Yuanqing FANG , Brian M. FOX , Brian S. LUCAS , Lawrence R. MCGEE , Filisaty VOUNATSOS , Sean H. WIEDEMANN , Sarah WORTMAN
IPC: A61K31/451 , C07D211/94 , C07D491/048 , C07C309/25 , C07C309/04 , C07C313/02 , C07C309/35 , C07D498/04 , C07D211/76
CPC classification number: A61K31/451 , C07D211/94 , C07D491/048 , C07C309/25 , C07C309/04 , C07C313/02 , C07C309/35 , C07D498/04 , C07D211/76 , C07B2200/13
Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
-
Patent Agency Ranking
公开(公告)号：US20180092898A1
公开(公告)日：2018-04-05
申请号：US15820830
申请日：2017-11-22
Applicant: AMGEN INC.
Inventor： Matthew BIO , Sebastien CAILLE , Brian COCHRAN , Yuanqing FANG , Brian M. FOX , Brian S. LUCAS , Lawrence R. MCGEE , Filisaty VOUNATSOS , Sean H. WIEDEMANN , Sarah WORTMAN
IPC: A61K31/451 , C07C309/35 , C07C309/25 , C07C309/04 , C07C313/02 , C07D211/76 , C07D211/94 , C07D491/048 , C07D498/04
CPC classification number: A61K31/451 , C07B2200/13 , C07C309/04 , C07C309/25 , C07C309/35 , C07C313/02 , C07D211/76 , C07D211/94 , C07D491/048 , C07D498/04
Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
-
公开(公告)号：US20160289190A1
公开(公告)日：2016-10-06
申请号：US15175824
申请日：2016-06-07
Applicant: AMGEN INC.
Inventor： Matthew BIO , Sebastien CAILLE , Brian COCHRAN , Yuanqing FANG , Brian M. FOX , Brian S. LUCAS , Lawrence R. McGEE , Filisaty VOUNATSOS , Sean H. WIEDEMANN , Sarah WORTMAN
IPC: C07D211/76
CPC classification number: A61K31/451 , C07B2200/13 , C07C309/04 , C07C309/25 , C07C309/35 , C07C313/02 , C07D211/76 , C07D211/94 , C07D491/048 , C07D498/04
Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
-
公开(公告)号：US20160287570A1
公开(公告)日：2016-10-06
申请号：US15175798
申请日：2016-06-07
Applicant: AMGEN INC.
Inventor： Matthew BIO , Sebastien CAILLE , Brian COCHRAN , Yuanqing FANG , Filisaty VOUNATSOS , Sarah WORTMAN
IPC: A61K31/451
CPC classification number: A61K31/451 , C07B2200/13 , C07C309/04 , C07C309/25 , C07C309/35 , C07C313/02 , C07D211/76 , C07D211/94 , C07D491/048 , C07D498/04
Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
-
公开(公告)号：US20200281912A1
公开(公告)日：2020-09-10
申请号：US16664103
申请日：2019-10-25
Applicant: AMGEN INC.
Inventor： Matthew BIO , Sebastien CAILLE , Brian COCHRAN , Yuanqing FANG , Brian M. FOX , Brian S. LUCAS , Lawrence R. MCGEE , Filisaty VOUNTSOS , Sean H. WIEDEMANN , Sarah WORTMAN
IPC: A61K31/451 , C07D211/94 , C07D491/048 , C07C309/25 , C07C309/04 , C07C313/02 , C07C309/35 , C07D498/04 , C07D211/76
Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
-
公开(公告)号：US20160289243A1
公开(公告)日：2016-10-06
申请号：US15175805
申请日：2016-06-07
Applicant: AMGEN INC.
Inventor： Matthew BIO , Sebastien CAILLE , Yuanqing FANG , Brian M. FOX , Brian S. LUCAS , Lawrence R. McGEE , Sean H. WIEDEMANN
IPC: C07D498/04 , C07C309/35
CPC classification number: A61K31/451 , C07B2200/13 , C07C309/04 , C07C309/25 , C07C309/35 , C07C313/02 , C07D211/76 , C07D211/94 , C07D491/048 , C07D498/04
Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
-
-
-
-
-
-
-
-
-
Search Results
11
records
(took 0.013 seconds)
