公开(公告)号：US20240210428A1

公开(公告)日：2024-06-27

申请号：US18287523

申请日：2022-04-12

Applicant: AMGEN INC.

Inventor： Vikashni Padmakumar ,  Evan Kruchowy ,  Daniel Coller ,  Opeyemi Babatola ,  Oscar Rosas ,  Gregory Evans ,  Stephen Flores

IPC: G01N35/00 ,  A61M5/31 ,  A61M5/315 ,  G01N35/04 ,  G06T7/00 ,  G06T7/50

CPC classification number: G01N35/00623 ,  G01N35/04 ,  G06T7/0004 ,  G06T7/50 ,  A61M5/3129 ,  A61M5/31511 ,  G06T2207/30108

Abstract: Automatic syringe quality control systems, apparatus and methods are provided. The automatic syringe quality control systems, apparatus and methods may determine a plunger depth within a syringe that has been pre-filled with a medication. The plunger depth may be based on digital image data.

公开(公告)号：US20250009976A1

公开(公告)日：2025-01-09

申请号：US18712768

申请日：2022-12-02

Applicant: AMGEN INC.

Inventor： Fatemeh Fallahianbijan ,  Shermeen A. Abbas ,  Albert Ju ,  Oscar Gonzales ,  Vikashni Padmakumar ,  Jeffrey A. Brown ,  Wael Mismar

IPC: A61M5/315

Abstract: A method of placing a plunger into a syringe barrel filled with a drug product. The method includes aligning a stopper with a longitudinal axis of a syringe barrel. The syringe barrel includes a proximal end, a distal end, and a reservoir. The drug product is disposed in the reservoir at the distal end. The method includes applying a vacuum pressure to the reservoir of the syringe barrel. The method includes pushing the stopper with a plunger rod into the reservoir of the syringe barrel to a first depth. The method includes removing the plunger rod from the reservoir of the syringe barrel after pushing the stopper to the first depth. The stopper migrates to a second depth that is different than the first depth in response to a pressure differential in the reservoir of the syringe barrel.

公开(公告)号：US20240208680A1

公开(公告)日：2024-06-27

申请号：US18288549

申请日：2022-05-19

Applicant: AMGEN INC.

Inventor： Devrishi Goswami ,  Jun Zhang ,  Deirdre Piedmonte ,  Vikashni Padmakumar ,  David Le ,  Maria Raquel Santos ,  Wei Qi

IPC: B65B3/00 ,  B65B3/12 ,  B65B3/28

CPC classification number: B65B3/003 ,  B65B3/12 ,  B65B3/28

Abstract: A method of filing a vial. The method includes providing a pump corresponding to a vial and setting a drip retraction parameter for the pump to any value equal to or less than 20 degrees. The method also includes setting a no adjustment limit for a fill weight of the vial to T1, with T1 being at or in a range of about 2% more or less than a fill weight of a target fill weight T0, wherein a process performance index Cpk (Cpk) for the vial throughout a fil cycle exceeds a minimum value.