公开(公告)号：US20250009976A1

公开(公告)日：2025-01-09

申请号：US18712768

申请日：2022-12-02

Applicant: AMGEN INC.

Inventor： Fatemeh Fallahianbijan ,  Shermeen A. Abbas ,  Albert Ju ,  Oscar Gonzales ,  Vikashni Padmakumar ,  Jeffrey A. Brown ,  Wael Mismar

IPC: A61M5/315

Abstract: A method of placing a plunger into a syringe barrel filled with a drug product. The method includes aligning a stopper with a longitudinal axis of a syringe barrel. The syringe barrel includes a proximal end, a distal end, and a reservoir. The drug product is disposed in the reservoir at the distal end. The method includes applying a vacuum pressure to the reservoir of the syringe barrel. The method includes pushing the stopper with a plunger rod into the reservoir of the syringe barrel to a first depth. The method includes removing the plunger rod from the reservoir of the syringe barrel after pushing the stopper to the first depth. The stopper migrates to a second depth that is different than the first depth in response to a pressure differential in the reservoir of the syringe barrel.