Patent search ap:("AMGEN INC.") AND inv:"Sean H. WIEDEMANN" Page 1

1.

发明申请
PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR 审中-公开

公开(公告)号：US20160289190A1

公开(公告)日：2016-10-06

申请号：US15175824

申请日：2016-06-07

Applicant: AMGEN INC.

Inventor： Matthew BIO , Sebastien CAILLE , Brian COCHRAN , Yuanqing FANG , Brian M. FOX , Brian S. LUCAS , Lawrence R. McGEE , Filisaty VOUNATSOS , Sean H. WIEDEMANN , Sarah WORTMAN

IPC: C07D211/76

CPC classification number: A61K31/451 , C07B2200/13 , C07C309/04 , C07C309/25 , C07C309/35 , C07C313/02 , C07D211/76 , C07D211/94 , C07D491/048 , C07D498/04

Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.

2.

发明申请
PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR 有权

公开(公告)号：US20220280496A1

公开(公告)日：2022-09-08

申请号：US17500039

申请日：2021-10-13

Applicant: AMGEN INC.

Inventor： Matthew BIO , Sebastien CAILLE , Brian COCHRAN , Yuanqing FANG , Brian M. FOX , Brian S. LUCAS , Lawrence R. MCGEE , Filisaty VOUNATSOS , Sean H. WIEDEMANN , Sarah WORTMAN

IPC: A61K31/451 , C07D211/94 , C07D491/048 , C07C309/25 , C07C309/04 , C07C313/02 , C07C309/35 , C07D498/04 , C07D211/76

Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.

3.

发明申请
PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR 审中-公开

公开(公告)号：US20200281912A1

公开(公告)日：2020-09-10

申请号：US16664103

申请日：2019-10-25

Applicant: AMGEN INC.

Inventor： Matthew BIO , Sebastien CAILLE , Brian COCHRAN , Yuanqing FANG , Brian M. FOX , Brian S. LUCAS , Lawrence R. MCGEE , Filisaty VOUNTSOS , Sean H. WIEDEMANN , Sarah WORTMAN

IPC: A61K31/451 , C07D211/94 , C07D491/048 , C07C309/25 , C07C309/04 , C07C313/02 , C07C309/35 , C07D498/04 , C07D211/76

Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.

4.

发明申请
PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR 审中-公开

公开(公告)号：US20160289243A1

公开(公告)日：2016-10-06

申请号：US15175805

申请日：2016-06-07

Applicant: AMGEN INC.

Inventor： Matthew BIO , Sebastien CAILLE , Yuanqing FANG , Brian M. FOX , Brian S. LUCAS , Lawrence R. McGEE , Sean H. WIEDEMANN

IPC: C07D498/04 , C07C309/35

CPC classification number: A61K31/451 , C07B2200/13 , C07C309/04 , C07C309/25 , C07C309/35 , C07C313/02 , C07D211/76 , C07D211/94 , C07D491/048 , C07D498/04

Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.

5.

发明公开
PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR 审中-公开

公开(公告)号：US20230301974A1

公开(公告)日：2023-09-28

申请号：US18313428

申请日：2023-05-08

Applicant: AMGEN INC.

Inventor： Matthew BIO , Sebastien CAILLE , Brian COCHRAN , Yuanqing FANG , Brian M. FOX , Brian S. LUCAS , Lawrence R. MCGEE , Filisaty VOUNATSOS , Sean H. WIEDEMANN , Sarah WORTMAN

IPC: A61K31/451 , C07D211/94 , C07D491/048 , C07C309/25 , C07C309/04 , C07C313/02 , C07C309/35 , C07D498/04 , C07D211/76

CPC classification number: A61K31/451 , C07D211/94 , C07D491/048 , C07C309/25 , C07C309/04 , C07C313/02 , C07C309/35 , C07D498/04 , C07D211/76 , C07B2200/13

Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.

6.

发明申请
PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR 审中-公开

公开(公告)号：US20180092898A1

公开(公告)日：2018-04-05

申请号：US15820830

申请日：2017-11-22

Applicant: AMGEN INC.

Inventor： Matthew BIO , Sebastien CAILLE , Brian COCHRAN , Yuanqing FANG , Brian M. FOX , Brian S. LUCAS , Lawrence R. MCGEE , Filisaty VOUNATSOS , Sean H. WIEDEMANN , Sarah WORTMAN

IPC: A61K31/451 , C07C309/35 , C07C309/25 , C07C309/04 , C07C313/02 , C07D211/76 , C07D211/94 , C07D491/048 , C07D498/04

CPC classification number: A61K31/451 , C07B2200/13 , C07C309/04 , C07C309/25 , C07C309/35 , C07C313/02 , C07D211/76 , C07D211/94 , C07D491/048 , C07D498/04

Abstract: The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.

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