公开(公告)号：US09458152B2

公开(公告)日：2016-10-04

申请号：US14920833

申请日：2015-10-22

Applicant: AMGEN INC.

Inventor： Matthew Weiss ,  Alessandro Boezio ,  Christiane Boezio ,  John R. Butler ,  Margaret Yuhua Chu-Moyer ,  Erin F. Dimauro ,  Thomas Dineen ,  Russell Graceffa ,  Angel Guzman-Perez ,  Hongbing Huang ,  Charles Kreiman ,  Daniel La ,  Isaac E. Marx ,  Benjamin Charles Milgram ,  Hanh Nho Nguyen ,  Emily Anne Peterson ,  Karina R. Vaida ,  Brian Sparling

IPC: A61K31/00 ,  C07D417/14 ,  C07D471/04 ,  C07D413/12 ,  C07D401/12 ,  C07D413/14 ,  C07D417/12 ,  C07C53/18 ,  C07D215/227 ,  C07D403/12 ,  C07D215/36 ,  C07D241/44 ,  C07D401/14

CPC classification number: C07D417/14 ,  C07C53/18 ,  C07D215/227 ,  C07D215/36 ,  C07D241/44 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04

Abstract: The present invention provides compounds of Formula I, and pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav1.7. The compounds are useful for the treatment of diseases associated with the activity of sodium channels such as pain disorders and itch. Also provided are pharmaceutical compositions containing compounds of the present invention.

公开(公告)号：US10668067B2

公开(公告)日：2020-06-02

申请号：US16319783

申请日：2017-07-20

Applicant: AMGEN INC.

Inventor： Matthew Weiss ,  John R. Butler ,  Benjamin Charles Milgram ,  Gwenaella Rescourio ,  Alessandro Boezio ,  Brian Andrew Sparling ,  Daniel La

IPC: A61K31/506 ,  A61K31/4439 ,  A61P25/00 ,  C07D213/75 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention provides compounds of Formula (I), as defined in the specification, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders, cough, or itch. Also provided are pharmaceutical compositions containing compounds of the present invention.

公开(公告)号：US10472356B2

公开(公告)日：2019-11-12

申请号：US15554801

申请日：2016-03-02

Applicant: AMGEN INC.

Inventor： Matthew Weiss ,  Benjamin Charles Milgram ,  Thomas Dineen ,  John Stellwagen ,  Angel Guzman-Perez ,  Alessandro Boezio ,  Issac E. Marx

IPC: A61K31/4375 ,  C07D471/04

Abstract: The present invention provides compounds of Formula (I), wherein: as defined in the specification, an enantiomer, diastereomer, atropisomer thereof, or a mixture thereof, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders, cough, or itch. Also provided are pharmaceutical compositions containing compounds of the present invention.