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    SYSTEM AND METHOD FOR DETECTING MULTIPLE-EXCITATION-INDUCED LIGHT IN A FLOW CHANNEL
    1.
    发明申请
    SYSTEM AND METHOD FOR DETECTING MULTIPLE-EXCITATION-INDUCED LIGHT IN A FLOW CHANNEL 有权
    用于检测流动通道中的多激发诱导光的系统和方法

    公开(公告)号：US20130200277A1

    公开(公告)日：2013-08-08

    申请号：US13657845

    申请日：2012-10-22

    Applicant: ACEA BIOSCIENCES, INC

    Inventor： Nan Li ,  Jian Wu ,  Ye Chen ,  Tianxing Wang ,  Xiaobo Wang

    IPC: G01N21/64

    CPC classification number: G01N21/645 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1459 ,  G01N21/64 ,  G01N21/6428 ,  G01N2015/1006 ,  G01N2015/1438 ,  G01N2015/149 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2201/06113 ,  G01N2201/0621

    Abstract: A system for detecting signal components of light induced by multiple excitation sources including: a flow channel including at least two spatially separated optical interrogation zones; a non-modulating excitation source that directs a light beam of a first wavelength at a near constant intensity onto a first of the optical interrogation zones; a modulating excitation source that directs a light beam of a second wavelength with an intensity modulated over time at a modulating frequency onto a second of the optical interrogation zones; a detector subsystem comprising a set of detectors configured to detect light emitted from particles flowing through the at least two optical interrogation zones and to convert the detected light into a total electrical signal; and a processor that determines signal components from the light detected from each of the optical interrogation zones.

    Abstract translation: 一种用于检测由多个激发源引起的光的信号分量的系统，包括：流路，包括至少两个空间分离的光询问区; 非调制激励源，其将第一波长的光束以接近恒定的强度引导到第一光学询问区上; 调制激励源，其将以调制频率随时间调制的第二波长的光束引导到第二光学询问区上; 检测器子系统，包括一组检测器，其被配置为检测从流过所述至少两个光询问区的颗粒发射的光并将检测到的光转换成总电信号; 以及处理器，其根据从每个光询问区检测的光来确定信号分量。

    System and method for detecting multiple-excitation-induced light in a flow channel
    4.
    发明授权
    System and method for detecting multiple-excitation-induced light in a flow channel 有权
    用于检测流道中多激发光的系统和方法

    公开(公告)号：US09568423B2

    公开(公告)日：2017-02-14

    申请号：US13657845

    申请日：2012-10-22

    Applicant: ACEA BIOSCIENCES, INC

    Inventor： Nan Li ,  Jian Wu ,  Ye Chen ,  Tianxing Wang ,  Xiaobo Wang

    IPC: G01N21/64 ,  G01F1/00 ,  G01N15/14 ,  G01N15/10

    CPC classification number: G01N21/645 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1459 ,  G01N21/64 ,  G01N21/6428 ,  G01N2015/1006 ,  G01N2015/1438 ,  G01N2015/149 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2201/06113 ,  G01N2201/0621

    Abstract: A system for detecting signal components of light induced by multiple excitation sources including: a flow channel including at least two spatially separated optical interrogation zones; a non-modulating excitation source that directs a light beam of a first wavelength at a near constant intensity onto a first of the optical interrogation zones; a modulating excitation source that directs a light beam of a second wavelength with an intensity modulated over time at a modulating frequency onto a second of the optical interrogation zones; a detector subsystem comprising a set of detectors configured to detect light emitted from particles flowing through the at least two optical interrogation zones and to convert the detected light into a total electrical signal; and a processor that determines signal components from the light detected from each of the optical interrogation zones.

    Abstract translation: 一种用于检测由多个激发源引起的光的信号分量的系统，包括：流路，包括至少两个空间分离的光询问区; 非调制激励源，其将第一波长的光束以接近恒定的强度引导到第一光学询问区上; 调制激励源，其将以调制频率随时间调制的第二波长的光束引导到第二光学询问区上; 检测器子系统，包括一组检测器，其被配置为检测从流过所述至少两个光询问区的颗粒发射的光并将检测到的光转换成总电信号; 以及处理器，其根据从每个光询问区检测的光来确定信号分量。

    SYSTEM AND METHOD FOR DETECTING MULTIPLE-EXCITATION-INDUCED LIGHT IN A FLOW CHANNEL
    5.
    发明申请
    SYSTEM AND METHOD FOR DETECTING MULTIPLE-EXCITATION-INDUCED LIGHT IN A FLOW CHANNEL 审中-公开

    公开(公告)号：US20200292454A1

    公开(公告)日：2020-09-17

    申请号：US16833235

    申请日：2020-03-27

    Applicant: ACEA Biosciences, Inc.

    Inventor： Nan Li ,  Jian Wu ,  Ye Chen ,  Tianxing Wang ,  Xiaobo Wang

    IPC: G01N21/64 ,  G01N15/14

    Abstract: A system for detecting signal components of light induced by multiple excitation sources including: a flow channel including at least two spatially separated optical interrogation zones; a non-modulating excitation source that directs a light beam of a first wavelength at a near constant intensity onto a first of the optical interrogation zones; a modulating excitation source that directs a light beam of a second wavelength with an intensity modulated over time at a modulating frequency onto a second of the optical interrogation zones; a detector subsystem comprising a set of detectors configured to detect light emitted from particles flowing through the at least two optical interrogation zones and to convert the detected light into a total electrical signal; and a processor that determines signal components from the light detected from each of the optical interrogation zones.

    SYSTEM AND METHOD FOR MONITORING CARDIOMYOCYTE BEATING, VIABILITY, MORPHOLOGY, AND ELECTROPHYSIOLOGICAL PROPERTIES
    8.
    发明申请
    SYSTEM AND METHOD FOR MONITORING CARDIOMYOCYTE BEATING, VIABILITY, MORPHOLOGY, AND ELECTROPHYSIOLOGICAL PROPERTIES 审中-公开
    用于监测心脏细胞凋亡，可变性，形态和电生理特性的系统和方法

    公开(公告)号：US20140203818A1

    公开(公告)日：2014-07-24

    申请号：US14092927

    申请日：2013-11-28

    Applicant: ACEA Biosciences, Inc.

    Inventor： Xiaobo Wang ,  Wei Ouyang ,  Nan Li ,  Tianxing Wang ,  Xiaoyu Zhang ,  Xiao Xu ,  Yama A. Abassi

    IPC: G01N27/02

    CPC classification number: G01N27/02 ,  G01N33/4836

    Abstract: Devices, systems and methods for monitoring excitable cells, such as cardiomyocytes, on microelectrode arrays that couple the electro-stimulation of excitable cells to induce or regulate cardiomyocyte beating and the simultaneous measurement of impedance and extracellular recording to assess changes in cardiomyocyte beating, viability, morphology or electrophysical properties in response to a plurality of treatments.

    Abstract translation: 用于监测微电极阵列上的可兴奋细胞（例如心肌细胞）的装置，系统和方法，其耦合可刺激细胞的电刺激以诱导或调节心肌细胞搏动，以及同时测量阻抗和细胞外记录以评估心肌细胞跳动，活力， 响应于多种处理的形态或电物理性质。

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