公开(公告)号：US20210389723A1

公开(公告)日：2021-12-16

申请号：US17412789

申请日：2021-08-26

申请人： ABS Global, Inc.

发明人： Daniel Mueth ,  Joseph Plewa ,  Jessica Shireman ,  Amy Anderson ,  Lewis Gruber ,  Neil Rosenbaum

IPC分类号： G03H1/00 ,  G02B21/32 ,  H05H3/04 ,  B01L3/00 ,  G01N15/02 ,  G01N33/49 ,  B01D21/01 ,  G01N33/487 ,  G01N21/64 ,  G01N33/50 ,  A61L2/08 ,  B01D21/26 ,  B03C1/00 ,  B04B13/00 ,  G01N27/447 ,  G21K5/08

摘要： The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

公开(公告)号：US11422504B2

公开(公告)日：2022-08-23

申请号：US17458947

申请日：2021-08-27

申请人： ABS Global, Inc.

发明人： Daniel Mueth ,  Joseph Plewa ,  Jessica Shireman ,  Amy Anderson ,  Lewis Gruber ,  Neil Rosenbaum

IPC分类号： G03H1/00 ,  G02B21/32 ,  H05H3/04 ,  B01L3/00 ,  G01N15/02 ,  G01N33/49 ,  B01D21/01 ,  G01N33/487 ,  G01N21/64 ,  G01N33/50 ,  A61L2/08 ,  B01D21/26 ,  B03C1/00 ,  B04B13/00 ,  G01N27/447 ,  G21K5/08 ,  G01N15/04 ,  G01N15/05 ,  G01N15/06 ,  G01N15/14 ,  B03C1/28 ,  B03C5/00 ,  G03H1/08 ,  G03H1/22 ,  G01N15/00 ,  B01D21/00 ,  G01N15/10

摘要： The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

公开(公告)号：US20210397127A1

公开(公告)日：2021-12-23

申请号：US17458947

申请日：2021-08-27

申请人： ABS Global, Inc.

发明人： Daniel Mueth ,  Joseph Plewa ,  Jessica Shireman ,  Amy Anderson ,  Lewis Gruber ,  Neil Rosenbaum

IPC分类号： G03H1/00 ,  G02B21/32 ,  H05H3/04 ,  B01L3/00 ,  G01N15/02 ,  G01N33/49 ,  B01D21/01 ,  G01N33/487 ,  G01N21/64 ,  G01N33/50 ,  A61L2/08 ,  B01D21/26 ,  B03C1/00 ,  B04B13/00 ,  G01N27/447 ,  G21K5/08

摘要： The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

公开(公告)号：US11415936B2

公开(公告)日：2022-08-16

申请号：US17412789

申请日：2021-08-26

申请人： ABS Global, Inc.

发明人： Daniel Mueth ,  Joseph Plewa ,  Jessica Shireman ,  Amy Anderson ,  Lewis Gruber ,  Neil Rosenbaum

IPC分类号： G03H1/00 ,  G02B21/32 ,  H05H3/04 ,  B01L3/00 ,  G01N15/02 ,  G01N33/49 ,  B01D21/01 ,  G01N33/487 ,  G01N21/64 ,  G01N33/50 ,  A61L2/08 ,  B01D21/26 ,  B03C1/00 ,  B04B13/00 ,  G01N27/447 ,  G21K5/08 ,  G01N15/04 ,  G01N15/05 ,  G01N15/06 ,  G01N15/14 ,  B03C1/28 ,  B03C5/00 ,  G03H1/08 ,  G03H1/22 ,  G01N15/00 ,  B01D21/00 ,  G01N15/10

摘要： The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

公开(公告)号：US11243494B2

公开(公告)日：2022-02-08

申请号：US16239297

申请日：2019-01-03

申请人： ABS Global, Inc.

发明人： Daniel Mueth ,  Joseph Plewa ,  Jessica Shireman ,  Amy Anderson ,  Lewis Gruber ,  Neil Rosenbaum

IPC分类号： G03H1/00 ,  G02B21/32 ,  H05H3/04 ,  B01L3/00 ,  G01N15/02 ,  G01N33/49 ,  B01D21/01 ,  G01N33/487 ,  G01N21/64 ,  G01N33/50 ,  A61L2/08 ,  B01D21/26 ,  B03C1/00 ,  B04B13/00 ,  G01N27/447 ,  G21K5/08 ,  B03C1/28 ,  B03C5/00 ,  G03H1/08 ,  G03H1/22 ,  G01N15/00 ,  B01D21/00

摘要： The invention, provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.