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    System, method, and product for imaging probe arrays with small feature sizes
    1.
    发明申请
    System, method, and product for imaging probe arrays with small feature sizes 有权
    用于成像具有小特征尺寸的探针阵列的系统，方法和产品

    公开(公告)号：US20120051663A1

    公开(公告)日：2012-03-01

    申请号：US13241970

    申请日：2011-09-23

    Applicant: Michael D. Kaiser ,  David R. Smith

    Inventor： Michael D. Kaiser ,  David R. Smith

    IPC: G06K9/36

    CPC classification number: G01N21/6458 ,  Y10S128/922

    Abstract: An embodiment of a method for resolving features on a probe array is described that, comprises acquiring a plurality of micro-shifted images of a region of a probe array; reconstructing an image of the probe array using the micro-shifted images; and deriving intensity values for one or more probe features disposed on the probe array from the reconstructed image.

    Abstract translation: 描述了用于解决探针阵列上的特征的方法的实施例，其包括获取探针阵列的区域的多个微移位图像; 使用微移位图像重建探针阵列的图像; 以及从重构图像导出设置在探针阵列上的一个或多个探针特征的强度值。

    System, method, and product for imaging probe arrays with small feature sizes
    2.
    发明授权
    System, method, and product for imaging probe arrays with small feature sizes 有权
    用于成像具有小特征尺寸的探针阵列的系统，方法和产品

    公开(公告)号：US08055098B2

    公开(公告)日：2011-11-08

    申请号：US11627876

    申请日：2007-01-26

    Applicant: Michael D. Kaiser ,  David R. Smith

    Inventor： Michael D. Kaiser ,  David R. Smith

    IPC: A61B8/00

    CPC classification number: G01N21/6458 ,  Y10S128/922

    Abstract: An embodiment of a method for resolving features on a probe array is described that, comprises acquiring a plurality of micro-shifted images of a region of a probe array; reconstructing an image of the probe array using the micro-shifted images; and deriving intensity values for one or more probe features disposed on the probe array from the reconstructed image.

    Abstract translation: 描述了用于解决探针阵列上的特征的方法的实施例，其包括获取探针阵列的区域的多个微移位图像; 使用微移位图像重建探针阵列的图像; 以及从重构图像导出设置在探针阵列上的一个或多个探测特征的强度值。

    System, method, and product for scanning of biological materials employing dual analog integrators
    3.
    发明授权
    System, method, and product for scanning of biological materials employing dual analog integrators 有权
    使用双模拟积分器扫描生物材料的系统，方法和产品

    公开(公告)号：US07317415B2

    公开(公告)日：2008-01-08

    申请号：US10913102

    申请日：2004-08-06

    Applicant: Michael D. Kaiser

    Inventor： Michael D. Kaiser

    IPC: H03M1/12

    CPC classification number: G01N21/6428 ,  C12Q1/6837 ,  G01J3/2803 ,  G01J3/4406 ,  G01N21/274 ,  G01N21/6452 ,  G01N2021/6471

    Abstract: In one embodiment, a system is described for reducing a dark period between successive data acquisition periods associated with the detection of one or more target molecules hybridized to at least one of a plurality of probes disposed upon a biological probe array. The system comprises a switch that alternately directs an analog signal between a first circuit and a second circuit, where a period of time is required to alternate between the first and second circuits; an integrator associated with the first circuit that integrates the analog signal to generate a first integrated value; a second integrator associated with the second circuit that integrates the analog signal to generate a second integrated value; and an analog/digital converter that produces a digital value for each of the first integrated value and the second integrated values.

    Abstract translation: 在一个实施例中，描述了一种系统，用于减少与检测与设置在生物探针阵列上的多个探针中的至少一个杂交的一个或多个靶分子相关联的连续数据采集周期之间的暗期。 该系统包括交替地引导第一电路和第二电路之间的模拟信号的开关，其中需要一段时间来在第一和第二电路之间交替; 与所述第一电路相关联的积分器，其对所述模拟信号进行积分以产生第一积分值; 与所述第二电路相关联的第二积分器，其对所述模拟信号进行积分以产生第二积分值; 以及模拟/数字转换器，其为第一积分值和第二积分值中的每一个产生数字值。

    System, Method, and Product for Imaging Probe Arrays with Small Feature Sizes
    4.
    发明申请
    System, Method, and Product for Imaging Probe Arrays with Small Feature Sizes 有权
    具有小特征尺寸的成像探头阵列的系统，方法和产品

    公开(公告)号：US20070197911A1

    公开(公告)日：2007-08-23

    申请号：US11627876

    申请日：2007-01-26

    Applicant: Michael D. Kaiser ,  David R. Smith

    Inventor： Michael D. Kaiser ,  David R. Smith

    IPC: A61B8/00

    CPC classification number: G01N21/6458 ,  Y10S128/922

    Abstract: An embodiment of a method for resolving features on a probe array is described that, comprises acquiring a plurality of micro-shifted images of a region of a probe array; reconstructing an image of the probe array using the micro-shifted images; and deriving intensity values for one or more probe features disposed on the probe array from the reconstructed image.

    Abstract translation: 描述了用于解决探针阵列上的特征的方法的实施例，其包括获取探针阵列的区域的多个微移位图像; 使用微移位图像重建探针阵列的图像; 以及从重构图像导出设置在探针阵列上的一个或多个探针特征的强度值。

    System, method, and product for imaging probe arrays with small feature size
    7.
    发明授权
    System, method, and product for imaging probe arrays with small feature size 有权
    用于成像具有小特征尺寸的探针阵列的系统，方法和产品

    公开(公告)号：US08520976B2

    公开(公告)日：2013-08-27

    申请号：US13241970

    申请日：2011-09-23

    Applicant: Michael D. Kaiser ,  David R. Smith

    Inventor： Michael D. Kaiser ,  David R. Smith

    IPC: G06K9/36 ,  G06K9/64 ,  G06K9/00 ,  A61B8/00

    CPC classification number: G01N21/6458 ,  Y10S128/922

    Abstract: An embodiment of a method for resolving features on a probe array is described that, comprises acquiring a plurality of micro-shifted images of a region of a probe array; reconstructing an image of the probe array using the micro-shifted images; and deriving intensity values for one or more probe features disposed on the probe array from the reconstructed image.

    Abstract translation: 描述了用于解决探针阵列上的特征的方法的实施例，其包括获取探针阵列的区域的多个微移位图像; 使用微移位图像重建探针阵列的图像; 以及从重构图像导出设置在探针阵列上的一个或多个探针特征的强度值。

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