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1.发明授权Immunostimulatory activity of immune modulatory oligonucleotides (IMO™) containing different lengths of palindromic segments 失效免疫调节寡核苷酸（IMO™）的免疫刺激活性含有不同长度的回文段公开(公告)号：US07786089B2
公开(公告)日：2010-08-31
申请号：US11641551
申请日：2006-12-19
CPC分类号： C12N15/117 , A61K39/39 , A61K48/00 , A61K2039/55561 , C07H21/00 , C07H21/04 , C12N2310/17 , C12N2310/315 , C12N2310/318 , C12N2310/336
摘要： The invention provides a palindromic immune modulatory nucleic acid. The invention also provides methods for generating, enhancing and modifying the immune response caused by palindromic immune modulatory compounds used for immunotherapy applications.
摘要翻译： 本发明提供了回文免疫调节核酸。 本发明还提供用于产生，增强和修饰由用于免疫治疗应用的回文免疫调节化合物引起的免疫应答的方法。
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2.发明申请IMMUNOSTIMULATORY ACTIVITY OF PALINDROMIC IMMUNE MODULATORY OLIGONUCLEOTIDES (IMO) CONTAINING DIFFERENT LENGTHS OF PALINDROMIC SEGMENTS 审中-公开含有不同长度的PALINDROMIC部分的海洋免疫调节剂寡核苷酸（IMO）的免疫活性公开(公告)号：US20100215646A1
公开(公告)日：2010-08-26
申请号：US12774192
申请日：2010-05-05
IPC分类号： A61K39/395 , A61P35/00 , A61P29/00 , A61P27/14 , A61P11/06 , A61P11/00 , A61P17/00 , A61K31/7088 , A61K39/00
CPC分类号： C12N15/117 , A61K39/39 , A61K48/00 , A61K2039/55561 , C07H21/00 , C07H21/04 , C12N2310/17 , C12N2310/315 , C12N2310/318 , C12N2310/336
摘要： The invention provides a palindromic immune modulatory nucleic acid. The invention also provides methods for generating, enhancing and modifying the immune response caused by palindromic immune modulatory compounds used for immunotherapy applications
摘要翻译： 本发明提供了回文免疫调节核酸。 本发明还提供用于产生，增强和修饰由用于免疫治疗应用的回文免疫调节化合物引起的免疫应答的方法
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3.发明授权Stabilized immune modulatory RNA (SIMRA) compounds for TLR7 and TLR8 有权用于TLR7和TLR8的稳定免疫调节RNA（SIMRA）化合物公开(公告)号：US08759310B2
公开(公告)日：2014-06-24
申请号：US13353905
申请日：2012-01-19
申请人： Ekambar R. Kandimalla , Tao Lan , Yukui Li , Dong Yu , Daqing Wang , Mallikarjuna Reddy Putta , Sudhir Agrawal
发明人： Ekambar R. Kandimalla , Tao Lan , Yukui Li , Dong Yu , Daqing Wang , Mallikarjuna Reddy Putta , Sudhir Agrawal
CPC分类号： C07K14/665 , A61K31/713 , A61K39/0005 , A61K39/395 , A61K39/3955 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/318 , C12N2310/3183 , C12N2310/321 , C12N2310/33 , C12N2310/331 , C12N2310/336 , C12N2310/3521
摘要： The invention relates to the therapeutic use of stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides RNA based oligoribonucleotides with improved nuclease and RNase stability and that have immune modulatory activity through TLR7 and/or TLR8.
摘要翻译： 本发明涉及稳定的寡核糖核苷酸作为免疫治疗应用的免疫调节剂的治疗用途。 具体地，本发明提供具有改进的核酸酶和核糖核酸酶稳定性的基于RNA的寡核糖核苷酸，并且通过TLR7和/或TLR8具有免疫调节活性。
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4.发明申请STABILIZED IMMUNE MODULATORY RNA (SIMRA) COMPOUNDS FOR TLR7 AND TLR8 有权稳定的免疫调节剂RNA（SIMRA）化合物用于TLR7和TLR8公开(公告)号：US20080171712A1
公开(公告)日：2008-07-17
申请号：US11697422
申请日：2007-04-06
申请人： Ekambar R. Kandimalla , Tao Lan , Yukui Li , Dong Yu , Daqing Wang , Mallikarjuna Reddy Putta , Sudhir Agrawal
发明人： Ekambar R. Kandimalla , Tao Lan , Yukui Li , Dong Yu , Daqing Wang , Mallikarjuna Reddy Putta , Sudhir Agrawal
IPC分类号： A61K48/00 , A61K39/395
CPC分类号： C07K14/665 , A61K31/713 , A61K39/0005 , A61K39/395 , A61K39/3955 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/318 , C12N2310/3183 , C12N2310/321 , C12N2310/33 , C12N2310/331 , C12N2310/336 , C12N2310/3521
摘要： The invention relates to the therapeutic use of stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides RNA based oligoribonucleotides with improved nuclease and RNase stability and that have immune modulatory activity through TLR7 and/or TLR8.
摘要翻译： 本发明涉及稳定的寡核糖核苷酸作为免疫治疗应用的免疫调节剂的治疗用途。 具体地，本发明提供具有改进的核酸酶和核糖核酸酶稳定性的基于RNA的寡核糖核苷酸，并且通过TLR7和/或TLR8具有免疫调节活性。
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5.发明申请STABILIZED IMMUNE MODULATORY RNA (SIMRA) COMPOUNDS FOR TLR7 AND TLR8 有权稳定的免疫调节剂RNA（SIMRA）化合物用于TLR7和TLR8公开(公告)号：US20130202584A1
公开(公告)日：2013-08-08
申请号：US13353905
申请日：2012-01-19
申请人： Ekambar R. Kandimalla , Tao Lan , Yukui Li , Dong Yu , Daqing Wang , Mallikarjuna Reddy Putta , Sudhir Agrawal
发明人： Ekambar R. Kandimalla , Tao Lan , Yukui Li , Dong Yu , Daqing Wang , Mallikarjuna Reddy Putta , Sudhir Agrawal
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K14/665 , A61K31/713 , A61K39/0005 , A61K39/395 , A61K39/3955 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/318 , C12N2310/3183 , C12N2310/321 , C12N2310/33 , C12N2310/331 , C12N2310/336 , C12N2310/3521
摘要： The invention relates to the therapeutic use of stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides RNA based oligoribonucleotides with improved nuclease and RNase stability and that have immune modulatory activity through TLR7 and/or TLR8.
摘要翻译： 本发明涉及稳定的寡核糖核苷酸作为免疫治疗应用的免疫调节剂的治疗用途。 具体地，本发明提供具有改进的核酸酶和核糖核酸酶稳定性的基于RNA的寡核糖核苷酸，并且通过TLR7和/或TLR8具有免疫调节活性。
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6.发明授权Stabilized immune modulatory RNA (SIMRA) compounds for TLR7 and TLR8 有权用于TLR7和TLR8的稳定免疫调节RNA（SIMRA）化合物公开(公告)号：US08106173B2
公开(公告)日：2012-01-31
申请号：US11697422
申请日：2007-04-06
申请人： Ekambar R. Kandimalla , Tao Lan , Yukui Li , Dong Yu , Daqing Wang , Mallikarjuna Reddy Putta , Sudhir Agrawal
发明人： Ekambar R. Kandimalla , Tao Lan , Yukui Li , Dong Yu , Daqing Wang , Mallikarjuna Reddy Putta , Sudhir Agrawal
CPC分类号： C07K14/665 , A61K31/713 , A61K39/0005 , A61K39/395 , A61K39/3955 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/318 , C12N2310/3183 , C12N2310/321 , C12N2310/33 , C12N2310/331 , C12N2310/336 , C12N2310/3521
摘要： The invention relates to the therapeutic use of stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides RNA based oligoribonucleotides with improved nuclease and RNase stability and that have immune modulatory activity through TLR7 and/or TLR8.
摘要翻译： 本发明涉及稳定的寡核糖核苷酸作为免疫治疗应用的免疫调节剂的治疗用途。 具体地，本发明提供具有改进的核酸酶和核糖核酸酶稳定性的基于RNA的寡核糖核苷酸，并且通过TLR7和/或TLR8具有免疫调节活性。
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