公开(公告)号：US20130143965A1

公开(公告)日：2013-06-06

申请号：US13685561

申请日：2012-11-26

申请人： Harry Cook ,  Martha Hamilton ,  Douglas Danielson ,  Colette Goderstad ,  Dayton T. Reardan

发明人： Harry Cook ,  Martha Hamilton ,  Douglas Danielson ,  Colette Goderstad ,  Dayton T. Reardan

IPC分类号： A61K31/19

CPC分类号： A61K47/14 ,  A61J1/00 ,  A61K9/0019 ,  A61K9/0095 ,  A61K31/19 ,  A61K31/191 ,  A61K47/02 ,  A61K47/08 ,  A61K47/12

摘要： Disclosed are formulations of gamma-hydroxybutyrate in an aqueous medium that are resistant to microbial growth. Also disclosed are formulations of gamma-hydroxybutyrate that are also resistant to the conversion into GBL. Disclosed are methods to treat sleep disorders, including narcolepsy, with these stable formulations of GHB. The present invention also provides methods to treat alcohol and opiate withdrawal, reduced levels of growth hormone, increased intracranial pressure, and physical pain in a patient.

公开(公告)号：US20120202880A1

公开(公告)日：2012-08-09

申请号：US13446940

申请日：2012-04-13

申请人： Harry Cook ,  Martha Hamilton ,  Douglas Danielson ,  Colette Goderstad ,  Dayton Reardan

发明人： Harry Cook ,  Martha Hamilton ,  Douglas Danielson ,  Colette Goderstad ,  Dayton Reardan

IPC分类号： A61K31/19 ,  A61P25/00

CPC分类号： A61K47/14 ,  A61J1/00 ,  A61K9/0019 ,  A61K9/0095 ,  A61K31/19 ,  A61K31/191 ,  A61K47/02 ,  A61K47/08 ,  A61K47/12

摘要： Disclosed are formulations of gamma-hydroxybutyrate in an aqueous medium that are resistant to microbial growth. Also disclosed are formulations of gammahydroxybutyrate that are also resistant to the conversion into GBL. Disclosed are methods to treat sleep disorders, including narcolepsy, with these stable formulations of GHB. The present invention also provides methods to treat alcohol and opiate withdrawal, reduced levels of growth hormone, increased intracranial pressure, and physical pain in a patient.

摘要翻译： 公开了在水性介质中抗微生物生长的γ-羟基丁酸盐的制剂。 还公开了γ-羟基丁酸酯的制剂，其也耐转化为GBL。 公开了用GHB的这些稳定制剂治疗睡眠障碍（包括发作性睡病）的方法。 本发明还提供了治疗患者的酒精和阿片剂戒断，生长激素水平降低，颅内压升高和身体疼痛的方法。

公开(公告)号：US20110039929A1

公开(公告)日：2011-02-17

申请号：US12913644

申请日：2010-10-27

申请人： Harry Cook ,  Martha Hamilton ,  Douglas Danielson ,  Colette Goderstad ,  Dayton T. Reardan

发明人： Harry Cook ,  Martha Hamilton ,  Douglas Danielson ,  Colette Goderstad ,  Dayton T. Reardan

IPC分类号： A61K31/19 ,  A61P25/00 ,  A61P5/06

CPC分类号： A61K47/14 ,  A61J1/00 ,  A61K9/0019 ,  A61K9/0095 ,  A61K31/19 ,  A61K31/191 ,  A61K47/02 ,  A61K47/08 ,  A61K47/12

摘要： Disclosed are formulations of gamma-hydroxybutyrate in an aqueous medium that are resistant to microbial growth. Also disclosed are formulations of gamma-hydroxybutyrate that are also resistant to the conversion into GBL. Disclosed are methods to treat sleep disorders, including narcolepsy, with these stable formulations of GHB. The present invention also provides methods to treat alcohol and opiate withdrawal, reduced levels of growth hormone, increased intracranial pressure, and physical pain in a patient.

摘要翻译： 公开了在水性介质中抗微生物生长的γ-羟基丁酸盐的制剂。 还公开了γ-羟基丁酸酯的制剂，其也耐转化为GBL。 公开了用GHB的这些稳定制剂治疗睡眠障碍（包括发作性睡病）的方法。 本发明还提供了治疗患者的酒精和阿片剂戒断，生长激素水平降低，颅内压升高和身体疼痛的方法。

公开(公告)号：US4106343A

公开(公告)日：1978-08-15

申请号：US801937

申请日：1977-05-31

申请人： Harry Cook

发明人： Harry Cook

IPC分类号： G01C5/06 ,  G01L9/06 ,  G01L7/14

CPC分类号： G01C5/06 ,  G01L9/06

摘要： A solid-state barometric altimeter-encoder. The atmospheric pressure is cared to a reference vacuum on a hybrid IC pressure transducer which generates a proportional signal. This analog signal is then converted into digital data, corrected for atmospheric to altitude non-linearity by use of a ROM look-up table, displayed as a digital readout and also converted to Grey code format for transponder MC (altitude) transmission.

摘要翻译： 固态气压高度计 - 编码器。 在产生比例信号的混合IC压力传感器上将大气压与参考真空进行比较。 然后将该模拟信号转换为数字数据，通过使用ROM显示表将其显示为数字读数，并将其转换为转发器MC（高度）传输的格雷码格式，以便大气到高度非线性。

公开(公告)号：US08324275B2

公开(公告)日：2012-12-04

申请号：US13446892

申请日：2012-04-13

申请人： Harry Cook ,  Martha Hamilton ,  Douglas Danielson ,  Colette Goderstad ,  Dayton T. Reardan

发明人： Harry Cook ,  Martha Hamilton ,  Douglas Danielson ,  Colette Goderstad ,  Dayton T. Reardan

IPC分类号： A01N37/00 ,  A01N31/00 ,  A61K31/19 ,  A61K31/045

CPC分类号： A61K47/14 ,  A61J1/00 ,  A61K9/0019 ,  A61K9/0095 ,  A61K31/19 ,  A61K31/191 ,  A61K47/02 ,  A61K47/08 ,  A61K47/12

摘要： Disclosed are formulations of gamma-hydroxybutyrate in an aqueous medium that are resistant to microbial growth. Also disclosed are formulations of gammahydroxybutyrate that are also resistant to the conversion into GBL. Disclosed are methods to treat sleep disorders, including narcolepsy, with these stable formulations of GHB. The present invention also provides methods to treat alcohol and opiate withdrawal, reduced levels of growth hormone, increased intracranial pressure, and physical pain in a patient.

公开(公告)号：US06472431B2

公开(公告)日：2002-10-29

申请号：US09470570

申请日：1999-12-22

申请人： Harry Cook ,  Martha Hamilton ,  Douglas Danielson ,  Colette Goderstad ,  Dayton Reardan

发明人： Harry Cook ,  Martha Hamilton ,  Douglas Danielson ,  Colette Goderstad ,  Dayton Reardan

IPC分类号： A61K3119

CPC分类号： A61K47/14 ,  A61J1/00 ,  A61K9/0019 ,  A61K9/0095 ,  A61K31/19 ,  A61K31/191 ,  A61K47/02 ,  A61K47/08 ,  A61K47/12

摘要： Disclosed are formulations of gamma-hydroxybutyrate in an aqueous medium that are resistant to microbial growth. Also disclosed are formulations of gamma-hydroxybutyrate that are also resistant to the conversion into GBL. Disclosed are methods to treat sleep disorders, including narcolepsy, with these stable formulations of GHB. The present invention also provides methods to treat alcohol and opiate withdrawal, reduced levels of growth hormone, increased intracranial pressure, and physical pain in a patient.

摘要翻译： 公开了在水性介质中抗微生物生长的γ-羟基丁酸盐的制剂。 还公开了γ-羟基丁酸酯的制剂，其也耐转化为GBL。 公开了用GHB的这些稳定制剂治疗睡眠障碍（包括发作性睡病）的方法。 本发明还提供了治疗患者的酒精和阿片剂戒断，生长激素水平降低，颅内压升高和身体疼痛的方法。

公开(公告)号：US20130267595A1

公开(公告)日：2013-10-10

申请号：US13787437

申请日：2013-03-06

申请人： Harry Cook ,  Martha Hamilton ,  Douglas Danielson ,  Colette Goderstad ,  Dayton T. Reardan

发明人： Harry Cook ,  Martha Hamilton ,  Douglas Danielson ,  Colette Goderstad ,  Dayton T. Reardan

IPC分类号： A61K31/19

CPC分类号： A61K47/14 ,  A61J1/00 ,  A61K9/0019 ,  A61K9/0095 ,  A61K31/19 ,  A61K31/191 ,  A61K47/02 ,  A61K47/08 ,  A61K47/12

摘要： Disclosed are formulations of gamma-hydroxybutyrate in an aqueous medium that are resistant to microbial growth. Also disclosed are formulations of gamma-hydroxybutyrate that are also resistant to the conversion into GBL. Disclosed are methods to treat sleep disorders, including narcolepsy, with these stable formulations of GHB. The present invention also provides methods to treat alcohol and opiate withdrawal, reduced levels of growth hormone, increased intracranial pressure, and physical pain in a patient.

公开(公告)号：US08263650B2

公开(公告)日：2012-09-11

申请号：US13446940

申请日：2012-04-13

申请人： Harry Cook ,  Martha Hamilton ,  Douglas Danielson ,  Colette Goderstad ,  Dayton T. Reardan

发明人： Harry Cook ,  Martha Hamilton ,  Douglas Danielson ,  Colette Goderstad ,  Dayton T. Reardan

IPC分类号： A61K31/34 ,  A61K31/215 ,  A61K31/185 ,  A61K31/19

CPC分类号： A61K47/14 ,  A61J1/00 ,  A61K9/0019 ,  A61K9/0095 ,  A61K31/19 ,  A61K31/191 ,  A61K47/02 ,  A61K47/08 ,  A61K47/12

摘要： Disclosed are formulations of gamma-hydroxybutyrate in an aqueous medium that are resistant to microbial growth. Also disclosed are formulations of gammahydroxybutyrate that are also resistant to the conversion into GBL. Disclosed are methods to treat sleep disorders, including narcolepsy, with these stable formulations of GHB. The present invention also provides methods to treat alcohol and opiate withdrawal, reduced levels of growth hormone, increased intracranial pressure, and physical pain in a patient.

摘要翻译： 公开了在水性介质中抗微生物生长的γ-羟基丁酸盐的制剂。 还公开了γ-羟基丁酸酯的制剂，其也耐转化为GBL。 公开了用GHB的这些稳定制剂治疗睡眠障碍（包括发作性睡病）的方法。 本发明还提供了治疗患者的酒精和阿片剂戒断，生长激素水平降低，颅内压升高和身体疼痛的方法。

公开(公告)号：US20120202879A1

公开(公告)日：2012-08-09

申请号：US13446892

申请日：2012-04-13

申请人： Harry Cook ,  Martha Hamilton ,  Douglas Danielson ,  Colette Goderstad ,  Dayton Reardan

发明人： Harry Cook ,  Martha Hamilton ,  Douglas Danielson ,  Colette Goderstad ,  Dayton Reardan

IPC分类号： A61K31/19 ,  A61P25/00 ,  A61P21/00

CPC分类号： A61K47/14 ,  A61J1/00 ,  A61K9/0019 ,  A61K9/0095 ,  A61K31/19 ,  A61K31/191 ,  A61K47/02 ,  A61K47/08 ,  A61K47/12

摘要： Disclosed are formulations of gamma-hydroxybutyrate in an aqueous medium that are resistant to microbial growth. Also disclosed are formulations of gammahydroxybutyrate that are also resistant to the conversion into GBL. Disclosed are methods to treat sleep disorders, including narcolepsy, with these stable formulations of GHB. The present invention also provides methods to treat alcohol and opiate withdrawal, reduced levels of growth hormone, increased intracranial pressure, and physical pain in a patient.

公开(公告)号：US07851506B2

公开(公告)日：2010-12-14

申请号：US11777877

申请日：2007-07-13

申请人： Harry Cook ,  Martha Hamilton ,  Douglas Danielson ,  Colette Goderstad ,  Dayton Reardan

发明人： Harry Cook ,  Martha Hamilton ,  Douglas Danielson ,  Colette Goderstad ,  Dayton Reardan

IPC分类号： A61K31/19

CPC分类号： A61K47/14 ,  A61J1/00 ,  A61K9/0019 ,  A61K9/0095 ,  A61K31/19 ,  A61K31/191 ,  A61K47/02 ,  A61K47/08 ,  A61K47/12

摘要： Disclosed are formulations of gamma-hydroxybutyrate in an aqueous medium that are resistant to microbial growth. Also disclosed are formulations of gamma-hydroxybutyrate that are also resistant to the conversion into GBL. Disclosed are methods to treat sleep disorders, including narcolepsy, with these stable formulations of GHB. The present invention also provides methods to treat alcohol and opiate withdrawal, reduced levels of growth hormone, increased intracranial pressure, and physical pain in a patient.

摘要翻译： 公开了在水性介质中抗微生物生长的γ-羟基丁酸盐的制剂。 还公开了γ-羟基丁酸酯的制剂，其也耐转化为GBL。 公开了用GHB的这些稳定制剂治疗睡眠障碍（包括发作性睡病）的方法。 本发明还提供了治疗患者的酒精和阿片剂戒断，生长激素水平降低，颅内压升高和身体疼痛的方法。