- 专利标题： Compositions and methods of using chondroitinase ABCI mutants
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申请号： US15230040申请日： 2016-08-05
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公开(公告)号： US09987340B2公开(公告)日： 2018-06-05
- 发明人: Anthony O. Caggiano , Andrea Vecchione , Jennifer Iaci
- 申请人： ACORDA THERAPEUTICS, INC.
- 申请人地址： US NY Ardsley
- 专利权人： Acorda Therapeutics, Inc.
- 当前专利权人： Acorda Therapeutics, Inc.
- 当前专利权人地址： US NY Ardsley
- 代理机构： Pepper Hamilton LLP
- 主分类号： C12N9/88
- IPC分类号： C12N9/88 ; C12N9/20 ; C12N9/24 ; C12N9/14 ; C12N15/64 ; C12P19/34 ; C12P21/06 ; C07H21/04 ; C07K1/00 ; A61M37/00 ; A61K38/00 ; A61K38/46 ; A61K38/51
摘要：
The present disclosure relates to protein and nucleic acid mutants of chondroitinase ABCI. Such nucleic acid mutants encode for chondroitinase ABCI mutant enzymes exhibiting altered chondroitin lyase activity or increased resistance to inactivation from stressors including UV light or heat. Methods of using such nucleic acid mutants encoding chondroitinase ABCI mutant enzymes is also provided.
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