发明授权
- 专利标题： A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
- 专利标题（中）： A环环氧化三萜类抗炎调节剂及其使用方法
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申请号： US14406854申请日： 2013-06-14
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公开(公告)号： US09556222B2公开(公告)日： 2017-01-31
- 发明人: Eric Anderson , Christopher F. Bender , Xin Jiang , Xiaofeng Liu , Haizhou Sun , Melean Visnick
- 申请人： REATA PHARMACEUTICALS, INC.
- 申请人地址： US TX Irving
- 专利权人： REATA PHARMACEUTICALS, INC.
- 当前专利权人： REATA PHARMACEUTICALS, INC.
- 当前专利权人地址： US TX Irving
- 代理机构： Parker Highlander PLLC
- 国际申请： PCT/US2013/045975 WO 20130614
- 国际公布： WO2013/188818 WO 20131219
- 主分类号： C07J71/00
- IPC分类号： C07J71/00 ; C07J75/00 ; C07D493/22 ; A61K31/336 ; C07J63/00
摘要：
Disclosed herein are novel A-ring epoxidized triterpenoid compounds and derivatives thereof, including those of the formula (I), wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits, and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example as antioxidant inflammation modulators, and compositions thereof are also provided.
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