发明授权
- 专利标题： In vitro sorting method
- 专利标题（中）： 体外分选方法
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申请号： US13733473申请日： 2013-01-03
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公开(公告)号： US09528106B2公开(公告)日： 2016-12-27
- 发明人: Andrew Griffiths , Dan Tawfik
- 申请人： Medical Research Council
- 申请人地址： GB London
- 专利权人： Medical Research Council
- 当前专利权人： Medical Research Council
- 当前专利权人地址： GB London
- 代理机构： Sunstein Kann Murphy & Timbers LLP
- 优先权： GB9714300.2 19970707; GB9806393.6 19980325
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12Q1/00 ; C12Q1/70 ; C12P21/06 ; C40B10/00 ; C40B30/08 ; C40B30/10 ; C12N15/10
摘要：
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalizing genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having a desired activity. The invention enables the in vitro evolution of nucleic acids by repeated mutagenesis and iterative applications of the method of the invention.
公开/授权文献
- US20130190189A1 IN VITRO SORTING METHOD 公开/授权日：2013-07-25
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