发明授权
US09499587B2 Gamma-AApeptides with potent and broad-spectrum antimicrobial activity
有权
Gamma-AA肽具有强效和广谱抗菌活性
- 专利标题： Gamma-AApeptides with potent and broad-spectrum antimicrobial activity
- 专利标题（中）： Gamma-AA肽具有强效和广谱抗菌活性
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申请号： US14374018申请日： 2013-01-23
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公开(公告)号： US09499587B2公开(公告)日： 2016-11-22
- 发明人: Jianfeng Cai , Youhong Niu , Haifan Wu , Shruti Padhee
- 申请人： Jianfeng Cai , Youhong Niu , Haifan Wu , Shruti Padhee
- 申请人地址： US FL Tampa
- 专利权人： UNIVERSITY OF SOUTH FLORIDA
- 当前专利权人： UNIVERSITY OF SOUTH FLORIDA
- 当前专利权人地址： US FL Tampa
- 代理机构： Saliwanchik, Lloyd & Eisenschenk
- 国际申请： PCT/US2013/022695 WO 20130123
- 国际公布： WO2013/112548 WO 20130801
- 主分类号： A61K38/04
- IPC分类号： A61K38/04 ; C07K5/12 ; A61K38/00 ; A61K38/12 ; C07K7/64 ; A61K38/08 ; G01N33/569 ; A61K45/06 ; A61K49/00 ; C07K7/06
摘要：
The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do not appear to lead to the development of microbial resistance in treated microorganisms. Thus, the disclosed γ-AApeptides can be used for the treatment of various medical conditions associated with pathogenic microorganisms.
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