发明授权
- 专利标题： Opsin-binding ligands, compositions and methods of use
- 专利标题（中）： 组氨酸 - 结合配体，组合物和使用方法
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申请号： US14352178申请日： 2012-10-19
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公开(公告)号： US09499464B2公开(公告)日： 2016-11-22
- 发明人: David S. Garvey , Gregory J. Larosa , Jeremy R. Greenwood , Leah L. Frye , Tan Quach , Jamie B. Cote , Judd Berman
- 申请人： Bikam Pharmaceuticals, Inc.
- 申请人地址： US MA Lexington
- 专利权人： BIKAM PHARMACEUTICALS, INC.
- 当前专利权人： BIKAM PHARMACEUTICALS, INC.
- 当前专利权人地址： US MA Lexington
- 代理机构： Troutman Sanders LLP
- 国际申请： PCT/US2012/000522 WO 20121019
- 国际公布： WO2013/058809 WO 20130425
- 主分类号： C07D209/34
- IPC分类号： C07D209/34 ; C07D307/83 ; C07C49/443 ; C07C49/553 ; C07C35/32 ; C07C69/75 ; C07C233/58
摘要：
Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic is visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
公开/授权文献
- US20140256782A1 Opsin-Binding Ligands, Compositions and Methods of Use 公开/授权日：2014-09-11
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