A medication reminder and compliance system including a pill box, a pill box and electronic device; or a pill box, electronic device and remote server. The pill box includes several detachable dosettes, each divided into several chambers having a door. A two-color LED is disposed beneath each chamber and is activated when a specific reminder time is reached. The LED initially illuminates the associated chamber with a green light but changes to a flashing red light if the door is not opened within a preset time. A switch engaged with the door deactivates the LED when the door is opened. The electronic device communicates with the pill box and alerts the patient when it is time to take medication. A remote server which communicates with both the pill box and electronic device can be programmed to control the reminder schedule and monitor the patient's compliance with a prescribed medication regimen.