发明授权
US09173876B2 Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
有权
（2S，3R）-N-2 - （（3-吡啶基）甲基）-1-氮杂双环[2.2.2]辛-3-基）-3,5-二氟苯甲酰胺的制备和治疗应用
![Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide](/docs/US/2015-11-03/US09173876B2/abs.jpg.600x600.jpg)
- 专利标题： Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
- 专利标题（中）： （2S，3R）-N-2 - （（3-吡啶基）甲基）-1-氮杂双环[2.2.2]辛-3-基）-3,5-二氟苯甲酰胺的制备和治疗应用
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申请号： US14518049申请日： 2014-10-20
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公开(公告)号： US09173876B2公开(公告)日： 2015-11-03
- 发明人: Merouane Bencherif , Nikolai Federov , Terry Hauser , Kristen G. Jordan , Sharon Rae Letchworth , Anatoly Mazurov , Julio A. Munoz , Jason Speake , Daniel Yohannes
- 申请人： Targacept, Inc.
- 代理机构： BRINKS GILSON & LIONE
- 主分类号： A61K31/439
- IPC分类号： A61K31/439 ; A61K31/444 ; C07D453/02
![Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide](/abs-image/US/2015/11/03/US09173876B2/abs.jpg.150x150.jpg)
摘要：
The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).
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