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发明授权
US08962626B2 Thienopyridazine compounds, their preparations, pharmaceutical compositions and uses 有权
噻吩并哒嗪化合物，其制剂，药物组合物和用途

Thienopyridazine compounds, their preparations, pharmaceutical compositions and uses
摘要：
The present invention relates to thienopyridazine compounds of formula (I), their pharmaceutically acceptable salts or hydrates, wherein R1 and R2 are independently H or C1-4 alkyl, R3 is a saturated or unsaturated 5- or 6-membered ring containing N, S or O, or its optical isomers, R4 is a halophenyl monosubstituted or disubstituted at any position. The present invention provides the preparation methods of these compounds, pharmaceutical compositions containing these compounds and the uses of these compounds, particularly in treating cancer.
摘要（中）：

本发明涉及式（I）的噻吩并哒嗪化合物及其药学上可接受的盐或水合物，其中R 1和R 2独立地为H或C 1-4烷基，R 3为饱和或不饱和的含有N，S 或O或其旋光异构体，R4是在任何位置被卤代苯基单取代或二取代的。 本发明提供了这些化合物的制备方法，含有这些化合物的药物组合物以及这些化合物的用途，特别是用于治疗癌症。

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