发明授权
- 专利标题： Micro-RNAS that control myosin expression and myofiber identity
- 专利标题（中）： 控制肌球蛋白表达和肌纤维识别的微RNA
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申请号： US13796884申请日： 2013-03-12
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公开(公告)号： US08962588B2公开(公告)日： 2015-02-24
- 发明人: Eric N. Olson , Eva van Rooij
- 申请人： The Board of Regents, The University of Texas System
- 申请人地址： US TX Austin
- 专利权人： The Board of Regents, The University of Texas System
- 当前专利权人： The Board of Regents, The University of Texas System
- 当前专利权人地址： US TX Austin
- 代理机构： Cooley LLP
- 主分类号： C12N15/11
- IPC分类号： C12N15/11 ; C07H21/02 ; C07H21/04
摘要：
The present invention relates to the identification of two microRNAs, miR-499 and miR-208b, that repress fast skeletal muscle contractile protein genes. Expression of miR-499 and/or miR-208b can be used to repress fast fiber genes and activate slow fiber genes in the treatment of musculoskeletal disorders. Inhibition of miR-499 and/or miR-208b is proposed as a treatment for cardiac hypertrophy, myocardial infarction, and/or heart failure. Pharmaceutical compositions comprising antagonists and agonists of miR-499 and miR-208b function are also disclosed.
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