发明授权
US08889838B2 Removal of serine proteases by treatment with finely divided silicon dioxide
有权
通过用细分二氧化硅处理去除丝氨酸蛋白酶
- 专利标题： Removal of serine proteases by treatment with finely divided silicon dioxide
- 专利标题（中）： 通过用细分二氧化硅处理去除丝氨酸蛋白酶
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申请号： US13830815申请日： 2013-03-14
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公开(公告)号： US08889838B2公开(公告)日： 2014-11-18
- 发明人: Wolfgang Teschner , Hans-Peter Schwarz , Ruth Madlener , Sonja Svatos , Azra Pljevljakovic , Alfred Weber
- 申请人： Baxter International Inc. , Baxter Healthcare S.A.
- 申请人地址： US IL Deerfield CH Glattpark (Opfikon)
- 专利权人： Baxter International Inc.,Baxter Healthcare SA
- 当前专利权人： Baxter International Inc.,Baxter Healthcare SA
- 当前专利权人地址： US IL Deerfield CH Glattpark (Opfikon)
- 代理机构： Morgan, Lewis & Bockius LLP
- 优先权： AU2010202125 20100526
- 主分类号： C07K1/30
- IPC分类号： C07K1/30 ; C07K1/18 ; A61K38/16 ; A61K9/00 ; A61K39/395 ; C07K16/06 ; A61K9/08 ; C07K1/36 ; A61K47/18 ; A61K38/17
摘要：
The present invention provides novel methods for reducing the serine protease and/or serine protease zymogen content of a plasma-derived protein composition. Also provided are methods for manufacturing plasma-derived protein compositions having reduced serine protease and\or serine protease zymogen content. Among yet other aspects, the present invention provides aqueous and lyophilized compositions of plasma-derived proteins having reduced serine protease and/or serine protease zymogen content. Yet other aspects include methods for treating, managing, and/or preventing a disease comprising the administration of a plasma-derived protein composition having a reduced serine protease or serine protease zymogen content.
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