Methods and apparatus for selectively switching one or more antennas in a multiple-input, multiple-output (MIMO) antenna array so as to mitigate interference with another RF interface within the same space-constrained device, based on radio frequency isolation. In one embodiment, the MIMO interface comprises a WLAN interface having a 2×2 or 3×3 array of antennae which are placed in a wireless device in an asymmetric fashion with respect to the antenna of the second interface, and the other interface comprises a PAN (e.g., Bluetooth) interface operating in an overlapping frequency band (e.g., ISM band). When both interfaces are operating, interference is mitigated through selectively switching off one or more of the MIMO antennae, and using the remaining antenna(e) having the best isolation from the Bluetooth antennae. This approach allows simultaneous operation of both interferences without significant degradation to user experience or the operation of either interface, and may also provide power savings critical to mobile device battery longevity.