发明授权
US08563599B2 Methods for synthesizing glycinols, glyceollins I and II, compositions of selected intermediates, and therapeutic uses thereof
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大豆醇，glyceollins I和II的合成方法，所选中间体的组成及其治疗用途
- 专利标题： Methods for synthesizing glycinols, glyceollins I and II, compositions of selected intermediates, and therapeutic uses thereof
- 专利标题（中）： 大豆醇，glyceollins I和II的合成方法，所选中间体的组成及其治疗用途
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申请号： US12921013申请日： 2009-03-03
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公开(公告)号： US08563599B2公开(公告)日： 2013-10-22
- 发明人: Paul W. Erhardt , Rahul Khupse , Jefferey G. Sarver , Thomas E. Cleveland , Stephen M. Boue , Thomas E. Wiese , Matthew E. Burow , John A. McLachlan
- 申请人： Paul W. Erhardt , Rahul Khupse , Jefferey G. Sarver , Thomas E. Cleveland , Stephen M. Boue , Thomas E. Wiese , Matthew E. Burow , John A. McLachlan
- 申请人地址： US DC Washington US LA New Orleans US OH Toledo
- 专利权人： The United States of America, represented by the Secretary of Agriculture,Xavier University of Louisiana,University of Toledo
- 当前专利权人： The United States of America, represented by the Secretary of Agriculture,Xavier University of Louisiana,University of Toledo
- 当前专利权人地址： US DC Washington US LA New Orleans US OH Toledo
- 代理机构： Miles & Stockbridge, P.C.
- 国际申请： PCT/US2009/035803 WO 20090303
- 国际公布： WO2009/111428 WO 20090911
- 主分类号： A61K31/352
- IPC分类号： A61K31/352
摘要：
Two distinct methods are disclosed and claimed for synthesizing glyceollin I plus glyceollin II as a mixture and as their pure forms. Stereochemical isomers and various synthetic intermediates are also synthesized and claimed for their novel compositions of matter. All compounds and their mixtures are claimed for use in formulations that are useful to treat or prevent cancer, or that have utility as selective estrogen receptor modulators, such formulations including enhanced or medical foods, dietary supplements and ethical pharmaceutical agents.
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