发明授权
- 专利标题： Methods for determining signal transduction activity in tumors
- 专利标题（中）： 确定肿瘤信号转导活性的方法
-
申请号： US13759765申请日： 2013-02-05
-
公开(公告)号： US08497080B2公开(公告)日： 2013-07-30
- 发明人: Mark Gustavson , Jennifer Giltnane , Marisa P. Dolled-Filhart , Robert L. Camp , David L. Rimm
- 申请人： HistoRx, Inc.
- 申请人地址： US CT New Haven US CT New Haven
- 专利权人： HistoRx, Inc.,Yale University
- 当前专利权人： HistoRx, Inc.,Yale University
- 当前专利权人地址： US CT New Haven US CT New Haven
- 代理机构： Cooper & Dunham LLP
- 代理商 John P. White
- 主分类号： G01N31/00
- IPC分类号： G01N31/00 ; G01N33/53
摘要：
The method of the invention pertains to determining signal transduction activity in a tissue section by immunohistochemistry techniques. The expression level of the receptor of interest is determined as well as the expression levels of one or more effector molecules of the receptor signal transduction pathway. Furthermore a combined ratio of expression levels of effector molecules in subcellular compartments with the receptor expression was found to have prognostic significance.
公开/授权文献
信息查询
