发明授权
US08492328B2 Biomarkers and methods for determining sensitivity to insulin growth factor-1 receptor modulators
有权
用于确定对胰岛素生长因子-1受体调节剂敏感性的生物标志物和方法
- 专利标题： Biomarkers and methods for determining sensitivity to insulin growth factor-1 receptor modulators
- 专利标题（中）： 用于确定对胰岛素生长因子-1受体调节剂敏感性的生物标志物和方法
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申请号： US12600504申请日： 2008-05-15
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公开(公告)号： US08492328B2公开(公告)日： 2013-07-23
- 发明人: Fei Huang , Xia Han , Rameh Hafezi , Jiwen Chen , Douglas Michael Robinson , Gayle M. Wittenberg , Ashok Ramesh Dongre , Joan M. Carboni , Ricardo M. Attar , Warren Hurlburt , Marco M. Gottardis
- 申请人： Fei Huang , Xia Han , Rameh Hafezi , Jiwen Chen , Douglas Michael Robinson , Gayle M. Wittenberg , Ashok Ramesh Dongre , Joan M. Carboni , Ricardo M. Attar , Warren Hurlburt , Marco M. Gottardis
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Stephen C. D'Amico; Paul Golian
- 国际申请： PCT/US2008/063621 WO 20080515
- 国际公布： WO2008/144345 WO 20081127
- 主分类号： A01N61/00
- IPC分类号： A01N61/00 ; G01N33/53
摘要：
IGF1R biomarkers useful in a method for identifying and monitoring a mammal that will respond therapeutically to a method of treating cancer comprising administering an IGF1R modulator, wherein the method comprises (a) exposing the mammal to the IGF1R modulator and (b) measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in (b) compared to the level of the biomarker in a mammal that has not been exposed to the IGF1R modulator indicates that the mammal will respond therapeutically to the method of treating cancer and (c) wherein the level of the biomarker in a mammal after exposure to a IGF1R modulator indicates that the mammal has responded therapeutically to the method of treating cancer.
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