Invention Grant
US08299076B2 Crystalline forms of 2-(2-flouro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
失效
2-（2-氟-4-碘苯基氨基）-N-（2-羟基乙氧基）-1,5-二甲基-6-氧代-1,6-二氢吡啶-3-甲酰胺的结晶形式
- Patent Title: Crystalline forms of 2-(2-flouro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
- Patent Title (中): 2-（2-氟-4-碘苯基氨基）-N-（2-羟基乙氧基）-1,5-二甲基-6-氧代-1,6-二氢吡啶-3-甲酰胺的结晶形式
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Application No.: US11914433Application Date: 2006-05-17
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Publication No.: US08299076B2Publication Date: 2012-10-30
- Inventor: Allison L. Marlow , Eli Wallace , Jeongbeob Seo , Joseph P. Lyssikatos , Hong Woon Yang , Jim Blake , Richard Anthony Storey , Rebecca Jane Booth , John David Pittam , John Leonard , Mark Richard Fielding
- Applicant: Allison L. Marlow , Eli Wallace , Jeongbeob Seo , Joseph P. Lyssikatos , Hong Woon Yang , Jim Blake , Richard Anthony Storey , Rebecca Jane Booth , John David Pittam , John Leonard , Mark Richard Fielding
- Applicant Address: US CO Boulder SE Sodertalje
- Assignee: Array Biopharma Inc.,Astrazeneca AB
- Current Assignee: Array Biopharma Inc.,Astrazeneca AB
- Current Assignee Address: US CO Boulder SE Sodertalje
- Agency: Viksnins Harris & Padys PLLP
- Agent John R. Moore, Esq.; Sarah S. Mastous, Agent
- International Application: PCT/US2006/019108 WO 20060517
- International Announcement: WO2007/044084 WO 20070419
- Main IPC: A01N43/58
- IPC: A01N43/58 ; A01N43/54 ; A01N43/40 ; C07D401/00 ; C07D239/02 ; C07D487/00 ; A61P35/00 ; A61P29/00
Abstract:
Disclosed are crystalline forms of 2-(2-fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
Public/Granted literature
- US20080280957A1 Heterocyclic Inhibitors of Mek and Methods of Use Thereof Public/Granted day:2008-11-13
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