Invention Grant
- Patent Title: Process for the preparation of carbapenem antibiotic
- Patent Title (中): 制备碳青霉烯类抗生素的方法
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Application No.: US12312649Application Date: 2007-11-20
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Publication No.: US08293894B2Publication Date: 2012-10-23
- Inventor: Andrew Gnanaprakasam , Nagappan Arumugam , Palanisamy Senthilkumar Udayampalayam , Pandi Suresh Pandian , Venugopal Sivasankaran , Ganapathy Veeramani , Henry Syril Sudhan , Gollapalli Venkateswara Rao
- Applicant: Andrew Gnanaprakasam , Nagappan Arumugam , Palanisamy Senthilkumar Udayampalayam , Pandi Suresh Pandian , Venugopal Sivasankaran , Ganapathy Veeramani , Henry Syril Sudhan , Gollapalli Venkateswara Rao
- Applicant Address: IN Chennai
- Assignee: Orchid Chemicals & Pharmaceuticals Limited
- Current Assignee: Orchid Chemicals & Pharmaceuticals Limited
- Current Assignee Address: IN Chennai
- Agency: Oliff & Berridge, PLC
- Priority: IN2153/CHE/2006 20061120; IN1000/CHE/2007 20070511; IN1395/CHE/2007 20070629
- International Application: PCT/IB2007/003564 WO 20071120
- International Announcement: WO2008/062279 WO 20080529
- Main IPC: C07D477/20
- IPC: C07D477/20

Abstract:
A process for the preparation of a carbapenem of formula (I): in amorphous form wherein R represents hydrogen or COOM and M represents hydrogen or sodium the process including condensing a compound of formula (II): wherein P′ denotes a carboxy protecting group, with a compound of formula (III): wherein P″ denotes a carboxy protecting group, in the presence of a base to yield a compound of formula (IV): deprotecting both the protecting groups in the compound of formula (IV) in the presence or absence of a sodium ion source, a solvent and in the presence or absence of CO2, gas, extracting the product into an aqueous medium, quenching the aqueous layer of into an alcohol at a temperature, and isolating the carbapenem compound of formula (I) in amorphous form.
Public/Granted literature
- US20090312539A1 AN IMPROVED PROCESS FOR THE PREPARATION OF CARBAPENEM ANTIBIOTIC Public/Granted day:2009-12-17
Information query
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