发明授权
US08268985B2 siRNA targeting amyloid beta (A4) precursor protein (APP)
有权
siRNA靶向淀粉样蛋白β（A4）前体蛋白（APP）
- 专利标题： siRNA targeting amyloid beta (A4) precursor protein (APP)
- 专利标题（中）： siRNA靶向淀粉样蛋白β（A4）前体蛋白（APP）
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申请号： US12924078申请日： 2010-09-20
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公开(公告)号： US08268985B2公开(公告)日： 2012-09-18
- 发明人: Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
- 申请人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
- 申请人地址： US CO Lafayette
- 专利权人： Dharmacon, Inc.
- 当前专利权人： Dharmacon, Inc.
- 当前专利权人地址： US CO Lafayette
- 代理机构： Dorf & Nelson LLP
- 代理商 Scott D. Locke, Esq.
- 主分类号： C07H21/04
- IPC分类号： C07H21/04
摘要：
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for APP.
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