发明授权
US08236796B2 Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
有权
芳基和杂芳基取代的四氢异喹啉及其用于阻断去甲肾上腺素,多巴胺和5-羟色胺的再摄取
- 专利标题: Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
- 专利标题(中): 芳基和杂芳基取代的四氢异喹啉及其用于阻断去甲肾上腺素,多巴胺和5-羟色胺的再摄取
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申请号: US12417598申请日: 2009-04-02
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公开(公告)号: US08236796B2公开(公告)日: 2012-08-07
- 发明人: Bruce F. Molino , Shuang Liu , Peter R. Guzzo , James P. Beck
- 申请人: Bruce F. Molino , Shuang Liu , Peter R. Guzzo , James P. Beck
- 申请人地址: US NY Albany US NY Princeton
- 专利权人: Albany Molecular Research, Inc.,Bristol-Myers Squibb Company
- 当前专利权人: Albany Molecular Research, Inc.,Bristol-Myers Squibb Company
- 当前专利权人地址: US NY Albany US NY Princeton
- 代理机构: LeClairRyan, a Professional Corporation
- 主分类号: C07D403/04
- IPC分类号: C07D403/04 ; C07D217/02 ; A61K31/47
摘要:
The compounds of the present invention are represented by the chemical structure found in Formula (I): wherein: the carbon atom designated * is in the R or S configuration; and X is a fused bicyclic carbocycle or heterocycle selected from the group consisting of benzofuranyl, benzo[b]thiophenyl, benzoisothiazolyl, benzoisoxazolyl, indazolyl, indolyl, isoindolyl, indolizinyl, benzoimidazolyl, benzooxazolyl, benzothiazolyl, benzotriazolyl, imidazo[1,2-a]pyridinyl, pyrazolo[1,5-a]pyridinyl, [1,2,4]triazolo[4,3 -a]pyridinyl, thieno[2,3-b]pyridinyl, thieno[3,2-b]pyridinyl, 1H-pyrrolo[2,3-b]pyridinyl, indenyl, indanyl, dihydrobenzocycloheptenyl, tetrahydrobenzocycloheptenyl, dihydrobenzothiophenyl, dihydrobenzofuranyl, indolinyl, naphthyl, tetrahydronaphthyl, quinolinyl, isoquinolinyl, 4H-quinolizinyl, 9aH-quinolizinyl, quinazolinyl, cinnolinyl, phthalazinyl, quinoxalinyl, benzo[1,2,3]triazinyl, benzo[1,2,4]triazinyl, 2H-chromenyl, 4H-chromenyl, and a fused bicyclic carbocycle or fused bicyclic heterocycle optionally substituted with substituents (1 to 4 in number) as defined in R14; with R1, R2, R3, R4, R5, R6, R7, R8, and R14 defined herein.
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