发明授权
US08071736B2 Nucleic acid molecules encodng a cathepsin L-like cysteine protease
有权
核酸分子编码组织蛋白酶L样半胱氨酸蛋白酶
- 专利标题: Nucleic acid molecules encodng a cathepsin L-like cysteine protease
- 专利标题(中): 核酸分子编码组织蛋白酶L样半胱氨酸蛋白酶
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申请号: US12512425申请日: 2009-07-30
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公开(公告)号: US08071736B2公开(公告)日: 2011-12-06
- 发明人: Andre R. Abad , Ronald D. Flannagan , Rafael Herrmann , Albert L. Lu , Billy F. McCutchen , James K. Presnail , Janet A. Rice , James F. Wong , Cao-Guo Yu
- 申请人: Andre R. Abad , Ronald D. Flannagan , Rafael Herrmann , Albert L. Lu , Billy F. McCutchen , James K. Presnail , Janet A. Rice , James F. Wong , Cao-Guo Yu
- 申请人地址: US IA Johnston US DE Wilmington
- 专利权人: Pioneer Hi-Bred International, Inc.,E.I. Dupont de Nemours and Company
- 当前专利权人: Pioneer Hi-Bred International, Inc.,E.I. Dupont de Nemours and Company
- 当前专利权人地址: US IA Johnston US DE Wilmington
- 代理机构: Alston & Bird LLP
- 主分类号: C07H21/04
- IPC分类号: C07H21/04 ; C12N1/20 ; C12N15/63 ; C12P21/00
摘要:
Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to comprise at least one proteolytic activation site that is sensitive to a plant protease or an insect gut protease are provided. Cleavage of the modified protoxin at the proteolytic activation site by a protease produces an active insect toxin. Methods of using the modified insect protoxin nucleic acid sequences and the polypeptides they encode to protect a plant from an insect pest are provided. Particular embodiments of the invention further provide modified insect protoxin compositions and formulations, expression cassettes, and transformed plants, plant cells, and seeds.
公开/授权文献
- US20090317891A1 PLANT ACTIVATION OF INSECT TOXIN 公开/授权日:2009-12-24
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