发明授权
- 专利标题： Pyrimidine derivatives as PI3K inhibitor and use thereof
- 专利标题（中）： 嘧啶衍生物作为PI3K抑制剂及其用途
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申请号： US12376039申请日： 2007-08-07
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公开(公告)号： US08022205B2公开(公告)日： 2011-09-20
- 发明人: Nobuo Shimma , Hirosato Ebiike , Jun Ohwada , Hatsuo Kawada , Kenji Morikami , Mitsuaki Nakamura , Miyuki Yoshida , Nobuya Ishii , Masami Hasegawa , Shun Yamamoto , Kohei Koyama
- 申请人： Nobuo Shimma , Hirosato Ebiike , Jun Ohwada , Hatsuo Kawada , Kenji Morikami , Mitsuaki Nakamura , Miyuki Yoshida , Nobuya Ishii , Masami Hasegawa , Shun Yamamoto , Kohei Koyama
- 申请人地址： JP Tokyo
- 专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人地址： JP Tokyo
- 代理机构： Foley & Lardner LLP
- 优先权： JP2006-216108 20060808; JP2007-118631 20070427
- 国际申请： PCT/JP2007/065396 WO 20070807
- 国际公布： WO2008/018426 WO 20080214
- 主分类号： C07D401/04
- IPC分类号： C07D401/04 ; C07D401/12 ; C07D405/04 ; C07D413/12
摘要：
A drug is provided that is useful as a preventive or therapeutic for cancer as a result of having superior PI3K inhibitory effects as well as superior stability in the body and water-solubility.A compound, or pharmaceutically acceptable salt thereof, represented by formula (I): [wherein, X represents a single bond, etc.; Y represents a single bond, etc. (provided that X and Y are not simultaneously single bonds); Z represents a hydrogen atom, etc.; m represents an integer of 1 or 2; and R1 represents a cyclic substituent].
公开/授权文献
- US20100069629A1 PYRIMIDINE DERIVATIVES AS PI3K INHIBITOR AND USE THEREOF 公开/授权日：2010-03-18
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