发明授权
US08008266B2 Methods of treating cancer using immunostimulatory oligonucleotides
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使用免疫刺激性寡核苷酸治疗癌症的方法
- 专利标题： Methods of treating cancer using immunostimulatory oligonucleotides
- 专利标题（中）： 使用免疫刺激性寡核苷酸治疗癌症的方法
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申请号： US10719493申请日： 2003-11-21
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公开(公告)号： US08008266B2公开(公告)日： 2011-08-30
- 发明人: Arthur M. Krieg , Alfred D. Steinberg , Dennis Klinman
- 申请人： Arthur M. Krieg , Alfred D. Steinberg , Dennis Klinman
- 申请人地址： US IA Iowa City US DC Washington US NY New York
- 专利权人： University of Iowa Foundation,The United States of America as represented by the Department of Health and Human Services,Coley Pharmaceutical Group, Inc.
- 当前专利权人： University of Iowa Foundation,The United States of America as represented by the Department of Health and Human Services,Coley Pharmaceutical Group, Inc.
- 当前专利权人地址： US IA Iowa City US DC Washington US NY New York
- 代理机构： Wolf, Greenfield & Sacks, P.C.
- 代理商 Gregg C. Benson
- 主分类号： C12N15/11
- IPC分类号： C12N15/11 ; C12N15/00 ; C12N5/00 ; A61K48/00 ; C07H21/02 ; C07H21/04 ; C12P21/06
摘要：
Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as a synthetic adjuvant.
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