发明授权
- 专利标题： Pyrazole compounds useful as protein kinase inhibitors
- 专利标题（中）： 用作蛋白激酶抑制剂的吡唑化合物
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申请号： US12545347申请日： 2009-08-21
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公开(公告)号： US07982037B2公开(公告)日： 2011-07-19
- 发明人: David Bebbington , Jean-Damien Charrier , Julian C. Golec , Andrew Miller , Ronald Knegtel
- 申请人： David Bebbington , Jean-Damien Charrier , Julian C. Golec , Andrew Miller , Ronald Knegtel
- 申请人地址： US MA Cambridge
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： US MA Cambridge
- 代理商 H. Joon Chung
- 主分类号： C07D403/12
- IPC分类号： C07D403/12
摘要：
This invention describes novel pyrazole compounds of formula IIIa: wherein R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx, Ry, R2, and R2′ are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
公开/授权文献
- US20090312543A1 PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS 公开/授权日：2009-12-17
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