发明授权
- 专利标题： Methods to identify patients at risk of developing adverse events during treatment with antidepressant medication
- 专利标题（中）： 确定在抗抑郁药物治疗期间发生不良事件风险的患者的方法
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申请号： US11925334申请日： 2007-10-26
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公开(公告)号： US07906283B2公开(公告)日： 2011-03-15
- 发明人: Francis J. McMahon , Gonzalo E. Laje , Silvia Paddock , Husseini K. Manji , A. John Rush
- 申请人： Francis J. McMahon , Gonzalo E. Laje , Silvia Paddock , Husseini K. Manji , A. John Rush
- 申请人地址： US DC Washington US IL Austin
- 专利权人： The United States of America as represented by the Department of Health and Human Services,Board of Regents, the University of Texas System
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services,Board of Regents, the University of Texas System
- 当前专利权人地址： US DC Washington US IL Austin
- 代理机构： Leydig, Voit & Mayer
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12P19/34 ; C07H21/02 ; C07H21/04
摘要：
The invention provides a method of screening patients to identify those patients more likely to exhibit an increased risk of treatment-emergent suicidal ideation comprising: (a) obtaining a sample of genetic material from the patients, and (b) assaying the sample for the presence of a genotype in the patients which is associated with an increased risk of treatment-emergent suicidal ideation, wherein the genotype is characterized by a polymorphism in a gene selected from the group consisting of glutamine receptor, ionotropic, kainate 2 (GRIK2); glutamate receptor ionotropic AMPA 3 (GRIA3); and combinations thereof.
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