发明授权
US07651838B2 Prenatal diagnosis method on isolated foetal cell of maternal blood
有权
母亲血液分离胎儿细胞产前诊断方法
- 专利标题： Prenatal diagnosis method on isolated foetal cell of maternal blood
- 专利标题（中）： 母亲血液分离胎儿细胞产前诊断方法
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申请号： US10695744申请日： 2003-10-30
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公开(公告)号： US07651838B2公开(公告)日： 2010-01-26
- 发明人: Patrizia Paterlini-Brechot
- 申请人： Patrizia Paterlini-Brechot
- 申请人地址： FR Paris FR Paris FR Paris
- 专利权人： Institut National de la Sante et de la Recherche Medicale,Assistance Publique-Hopitaux de Paris,Universite Rene Descartes Paris 5
- 当前专利权人： Institut National de la Sante et de la Recherche Medicale,Assistance Publique-Hopitaux de Paris,Universite Rene Descartes Paris 5
- 当前专利权人地址： FR Paris FR Paris FR Paris
- 代理机构： Birch, Stewart, Kolasch & Birch, LLP
- 优先权： FR0105824 20010430
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12P19/34 ; G01N33/53
摘要：
The invention concerns a novel non-invasive prenatal diagnostic method implemented with a sample of maternal blood. Said method enables prenatal diagnosis on isolated non-apoptotic epithelial foetal cells of maternal blood after they have been enriched by filtration, morphologically or immunologically and genetically analysed. Said method is advantageous in that it is perfectly harmless for the mother and the foetus and provides a highly sensitive and specific diagnosis. It enables early detection of a genetic or chromosomal abnormality of the foetus, of a genetic or infectious (viral, bacterial or parasitic) pathology of the foetus, of accurate genotype, and in particular of the genetic sex of the foetus.
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