发明授权
US07605273B2 Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors
有权
用作激酶抑制剂的芳基取代的吡唑酰胺化合物
- 专利标题： Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors
- 专利标题（中）： 用作激酶抑制剂的芳基取代的吡唑酰胺化合物
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申请号： US12118794申请日： 2008-05-12
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公开(公告)号： US07605273B2公开(公告)日： 2009-10-20
- 发明人: Alaric J. Dyckman , Jagabandhu Das , Katerina Leftheris , Chunjian Liu , Rulin Zhao , Bang-Chi Chen , Stephen T. Wrobleski
- 申请人： Alaric J. Dyckman , Jagabandhu Das , Katerina Leftheris , Chunjian Liu , Rulin Zhao , Bang-Chi Chen , Stephen T. Wrobleski
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Laurelee A. Duncan
- 主分类号： C07D231/14
- IPC分类号： C07D231/14
摘要：
The present invention relates to compounds having the formula, and pharmaceutically-acceptable salts, prodrugs, solvates, isomers, and/or hydrates thereof, wherein Q is an optionally-substituted phenyl, pyridyl, pyridazinyl, pyrimidinyl, or pyrazinyl ring; R2 is alkyl or an amino group as defined herein; and Z is optionally-substituted oxadiazolyl or —C(═O)NR6, wherein R6 is lower alkyl or cyclopropyl. The compounds are surprisingly advantageous in preparing pharmaceutical compositions for treating p38 kinase related conditions and/or in methods of treating conditions associated with the activity of p38 kinase in a patient.
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