Invention Grant
- Patent Title: Method for preparing taxane derivatives
- Patent Title (中): 紫杉烷衍生物的制备方法
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Application No.: US08256736Application Date: 1994-08-02
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Publication No.: US06596880B1Publication Date: 2003-07-22
- Inventor: Elie Fouque , Jean-Manuel Mas
- Applicant: Elie Fouque , Jean-Manuel Mas
- Priority: FR9201379 19920207
- Main IPC: C07D30514
- IPC: C07D30514

Abstract:
This invention relates to a method for preparing taxane derivatives of general formula (I) by esterification at a temperature between −10 and 60° C. of a derivative of baccatine III or 10-deacetyl baccatine III of general formula (II) by means of an acid of general formula (III), followed by replacement of the protective groupings G1, G2 and R2 of the resulting product by hydrogen atoms. In formulae (I), (II) or (III), Ar stands for an aryl radical; R stands for hydrogen or acetyl; R1 is benzoyl or ter.butoxycarbonyl; G1 is a hydroxy function protective grouping, G2 stands for the acetyl radical or a hydroxy function protective grouping, and R2 stands for a hydroxy function protective grouping.
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